Lokshin, Lockshin (Russian: Локшин) is a Jewish surname. Notable people with the surname include:
- Aleksandr Lokshin (1920–1987), Russian composer of classical music
- Arnold Lockshin (born 1939), American-born Russian scientist
- Mikhail Lockshin (born 1981), American-born Russian film director
- Richard A. Lockshin (born 1937), American cell biologist
- Steve Lockshin
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