Lefranc is a surname. Notable people with the surname include:
- Christelle Lefranc (born 1980), French fashion model from Paris, France
- Jean Georges Lefranc de Pompignan (1715–1790), French clergyman and younger brother of Jean-Jacques
- Jean-Jacques Lefranc, Marquis de Pompignan (1709–1784), French jurist, man of letters and gardener
- Jean-Marc Lefranc (born 1947), member of the National Assembly of France
- Victor Lefranc (1809–1883), French lawyer and politician, moderated republican, Minister of Agriculture and Trade, then Interior Minister
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