LIPN
Identifiers
Aliases	LIPN, ARCI8, LI4, LIPL4, bA186O14.3, lipase family member N
External IDs	OMIM: 613924 MGI: 1917416 HomoloGene: 66969 GeneCards: LIPN
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.31 Start 88,759,982 bp[1] End 88,779,626 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C1 Start 34,044,758 bp[2] End 34,062,318 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte skin of abdomen blood bone marrow appendix right lung bone marrow cells spleen upper lobe of left lung smooth muscle tissue Top expressed in lip esophagus zone of skin vastus lateralis muscle skin of abdomen spleen ear stomach major salivary gland submandibular gland More reference expression data BioGPS n/a
Gene ontology Molecular function hydrolase activity hydrolase activity, acting on ester bonds lipoprotein lipase activity lipase activity Cellular component extracellular region intracellular membrane-bounded organelle Biological process lipid catabolic process lipid metabolism cornification cellular lipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 643418 70166 Ensembl ENSG00000204020 ENSMUSG00000024770 UniProt Q5VXI9 Q3U4B4 RefSeq (mRNA) NM_001102469 NM_027340 RefSeq (protein) NP_001095939 NP_081616 Location (UCSC) Chr 10: 88.76 – 88.78 Mb Chr 19: 34.04 – 34.06 Mb PubMed search [3] [4]
Wikidata
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Lipase family member N is a protein that in humans is encoded by the LIPN gene. ^[5]

Function

The gene encodes a lipase that is highly expressed in granular keratinocytes in the epidermis, and plays a role in the differentiation of keratinocytes. Mutations in this gene are associated with lamellar ichthyosis type 4. [provided by RefSeq, Dec 2011].

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.