José León or José de León may refer to the following people:
In arts and entertainment
- José León Sánchez (1929–2022), Costa Rican novelist
- Joey de Leon (born 1946), born José María Ramos de León Jr., Filipino comedian and actor
In government and politics
- José de León y Echales (died 1699), Spanish governor of Trinidad
- José León Sandoval (fl 1845-1847), Nicaraguan president
- José María León Jiménez (1893-1936), Spanish politician
- José Antonio León Mendivil (born 1946), Mexican politician
- José Gaudencio León Castañeda (born 1960), Mexican politician
- Jose Luis León Perea (born 1970), Mexican politician
Sportspeople
- José León Gómez (Pepe León, born 1935), Spanish former football club chairman
- José Vicente León (born 1943), Spanish swimmer
- José DeLeón (born 1960), Dominican baseball pitcher
- José León (baseball) (born 1976), Puerto Rican baseball third baseman
- José De León (born 1992), Puerto Rican baseball pitcher
- José León (footballer) (born 1995), Spanish footballer
Other people
- José de León Toral (1900-1929), Roman Catholic extremist
- José León Asensio (born 1934), Dominican businessman
- José León de Carranza Bridge, Spanish steel bridge in Cádiz
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