Jean-René is a French masculine given name. Notable people with the name include:
- Jean René Allard (1930–2020), a former politician in Manitoba, Canada
- Jean René Baroux (1922–1992), a veteran of the second world war and writer
- Jean René Bazaine (1904–2001), a French painter
- Jean-René Bernaudeau (born 1956), a French former professional road bicycle racer
- Jean René Constant Quoy (1790–1869), a French zoologist
- Jean-René Cruchet (1875–1959), a French pathologist
- Jean René Gauguin (1881–1961), a French/Danish sculptor
- Jean-René Jérôme (1942–1991), a Haitian painter and sculptor
- Jean-René Lecerf (born 1951), a French politician and a member of the Senate of France
- Jean-René Lisnard (born 1979), a professional tennis player from Monaco
- Jean-René Marsac (born 1954), a member of the National Assembly of France
- Jean René Akono (born 1967), Camaroonian volleyball player
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