Jean-Louis is a given name, especially for French males.

Notable people named "Jean-Louis" include:

• Jean-Louis Alléon-Dulac, French naturalist
• Jean-Louis Aubert, French singer-songwriter, guitarist, composer and producer
• Jean-Louis Baribeau, Canadian politician and a Member of the House of Commons
• Jean-Louis Barrault, French actor, director and mime artist
• Jean-Louis Baudelocque, French obstetrician
• Jean-Louis Beaudry, Canadian politician and entrepreneur
• Jean-Louis Beffa, French businessman
• Jean-Louis Béland, Canadian politician and Member of the National Assembly of Quebec
• Jean-Louis Bergheaud, better known as Jean-Louis Murat
• Jean-Louis Berlandier, French-Mexican naturalist, physician, and anthropologist
• Jean Louis Berthauldt (1907–1997), a French-born costume designer also known as Jean Louis
• Jean-Louis Borloo, French politician
• Jean-Louis Bourlanges, French politician
• Jean-Louis Bruguière, French judge
• Jean-Louis Buffet, French musical instrument maker
• Jean-Louis Carra (fr) (1742–1793), a French activist and politician
• Jean-Louis Gassée (born 1944), best known as an executive at Apple Computer (1981–1990), later founder of Be Inc
• Jean-Louis Koszul, French mathematician
• Jean-Louis Lefebvre de Cheverus, a French-born American cardinal
• Jean-Louis Loday, French mathematician
• Jean-Louis Mandengue (born 1971), a French boxer
• Jean-Louis Masurel, a French businessman
• Jean-Louis Michel (fencer), Dominican Creole master in the art of fencing
• Jean-Louis Murat, French singer
• Jean-Louis Palladin, French chef of eponymous restaurant in Washington, DC
• Jean-Louis Schneiter, French politician
• Jean-Louis Thiériot (born 1969), French politician
• Jean-Louis Valois French professional footballer
• Jean-Louis Vieillard-Baron (born 1944), French philosopher

As a surname

• Girardin Jean-Louis, American academic
• Jimmy Jean-Louis, Haitian actor
• Joseph Mécène Jean-Louis, Haitian judge
• Marie-Denise Fabien Jean-Louis (born 1944), Haitian physician and politician