James Sharpe may refer to:
- James Sharpe (Australian politician) (1868–1935)
- James Sharpe (Canadian politician) (1846–1935), English-born pioneer and politician in Ontario
- James Sharpe (Dutch politician) (born 1962), businessman and athlete
- James Sharpe (Jesuit) (1577–1630), English professor of scripture
- James Sharpe (historian), University of York
See also
- James Sharp (disambiguation)
- Sharpe James (born 1936), politician from New Jersey
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