James Sanders may refer to:
Sports
- James Sanders (American football) (born 1983), American football safety
- Twiggy Sanders (James Sanders), member of the Harlem Globetrotters
- Jimmy Sanders (footballer) (1920–2003), English footballer
- Jimmy Sanders (baseball) (1902–1975), minor league baseball player and manager
- Jim Sanders (rugby league) (1900–1981), New Zealand international
Politicians
- James Sanders Jr. (born 1957), New York State Senator, 2013-
- James Sanders Holman (1804–1867), first mayor of Houston, Texas
Others
- James Sanders (architect) (born 1955), architect, designer, and writer in New York City
- James A. Sanders (1927–2020), Biblical scholar
- James C. Sanders (1926–2018), American businessman and administrator of the Small Business Administration
- Murder of James Sanders, murdered while showing a diamond ring that was listed for sale in Craigslist
- Speed Demon (comics), also known as James Sanders, a Marvel Comics character
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