Kansas City metropolitan area

I-35 enters Missouri two miles (3.2 km) southwest of Downtown Kansas City as a six-lane highway. After merging with Southwest Trafficway (exit 1A) and Broadway Boulevard (exit 1B), it becomes an eight-lane freeway and continues north to downtown, where it serves as the west and north legs of the Downtown Loop. Along the loop's northern edge, I-35 runs concurrent with I-70 immediately west of Broadway Boulevard and carries six lanes of traffic with a speed limit of 45 mph (72 km/h). After leaving the loop, I-29 begins, and I-35 runs concurrent with it. Both Interstates, together, cross the Missouri River on the Christopher S. Bond Bridge.^[2][3]

Daviess and Harrison counties

I-35 continues north from Cameron, intersecting US 69 (exit 61) as it crosses from the west- to the eastside of the highway before intersecting Route 6 (exit 64), providing access to Weatherby to the west of I-35. The Route 6 exit also provides access to the Interstate 35 Speedway, located in Winston. North of the interchange with Route 6, US 69 intersects I-35 again (exit 68) and, for the remainder of its route, stays to the west of I-35. Between Route DD (exit 72), providing local access to farmland, and Route C (exit 78), providing access to Pattonsburg, I-35 crosses the Grand River west of the Elam Bend Conservation Area. A final interchange with Route B and Route N (exit 80), providing access to Coffey, mark the last exit inside of Daviess County, and I-35 enters Harrison County.^[2][4]

Route AA and Route H (exit 84), which provides access to Gilman City to the east, are the first interchange with in Harrison County as I-35 continues northeasterly through northern Missouri, intersecting Route 13 (exit 88) south of the county seat, Bethany. Two interchanges provide access to Bethany, one with US 136 (exit 92) and one with U.S. Route 69 Spur (US 69 Spur, exit 93). Route A (exit 99) provides access to the town of Ridgeway to the east of the Interstate, and Route N (exit 106) further north provides access to Eagleville to the west and Blythedale to the east. Rest stops for both directions of travel are north of Route N, as well as a welcome center for motorists traveling southbound before intersecting US 69 (100th Street, exit 114) before crossing into Iowa.^[2][5]

Transit

Jefferson Lines provides intercity bus service along the length of I-35 in Missouri serving three communities along the route. The Kansas City Bus Station serves as a major transfer point along the I-35 route.^[6]

Cameron business route

Interstate 35 Business (I-35 Bus.) is a business loop of I-35 in the town of Cameron, stretching just over three miles (4.8 km) between exits 52 and 54 on the westside of I-35.

Major intersections

The entire route is in Cameron.

County	mi[8]	km	Destinations	Notes
Clinton	0.000	0.000	Route BB	Continuation east beyond I-35 exit 52
			I-35 / Route 110 (CKC) – Bethany, Kansas City	Counterclockwise terminus; I-35 exit 52
	0.867	1.395	US 69 south (Walnut Street south)	South end of concurrency with US 69
DeKalb	2.024	3.257	US 36 Bus. west	South end of concurrency with US 36 Bus.; former US 36
	2.378	3.827	US 36 Bus. ends US 69 north (Walnut Street north) / US 36 west – St. Joseph, Winston	Interchange; north end of concurrency with US 69/US 36 Bus., west end of concurrency with US 36
	3.233	5.203	Route 110 (CKC) west / I-35 – Bethany, Kansas City	Clockwise terminus; I-35 exit 54
			US 36 / Route 110 (CKC) east	Continuation beyond I-35 exit 54; east end of concurrency with US 36
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus