Interior North South Highway
Route information
Length	186 km (116 mi)
Major junctions
Northwest end	Ranau (continues as Pan Borneo Highway)
Major intersections	FT 22 Federal Route 22 FT 500 Malaysia Federal Route 500 FT 501 Jalan Penampang SA2 Jalan Ranau-Tambunan Kimanis-Keningau Highway Jalan Tawau-Keningau
Southeast end	Kemabung (continues to Tomani)
Location
Country	Malaysia
Primary destinations	Tambunan, Keningau, Sook(continues to Tawau), Tenom
Highway system
Highways in Malaysia Expressways Federal State

Interior North South Highway is a federal highway in Sabah, Malaysia, connecting Ranau to Kemabung. It serves as the main highway to replace Malaysia Federal Route 500 from Kota Kinabalu to towns and villages in the Interior Division of Sabah.

The length of the entire highway is expected to be about 186 kilometres (116 mi) for the Malaysian section.

List of interchanges

Km	Exit	Interchange	To	Remarks
		Ranau	North Mamut Southwest SA2 Jalan Ranau-Tambunan SA2Tambunan FT 500Keningau	Junctions
		-- m above sea level		Tambunan bound, Engage lower gear
		Tambunan Tambunan Roundabout	SA2 Jalan Ranau-Tambunan Ranau Kundasang Sandakan	Roundabout
		Tambunan	Tambunan town centre	Roundabout
		-- m above sea level		Keningau bound, Engage lower gear
		Apin-Apin		Junctions
		Keningau Town Hospital	Keningau Town Hospital	Roundabout
		Keningau	Kimanis-Keningau Highway Northwest Crocker Range National Park Kimanis	Roundabout
		Keningau Jalan Keningau-Sook	Jalan Keningau-Sook Sook Nabawan Kalabakan Tawau	Signalised T-junction
		Jalan Patikang Ulu	Jalan Patikang Ulu Kimanis	T-junction
		Melalap
		Tenom	Jalan Tenom-Ponontomon Ponontomon Sabah Agriculture Park	Roundabout
			Southwest SA3 Jalan Tenom-Sipitang Sipitang Sindumin Lawas
		-- m above sea level		Tenom bound, Engage lower gear
		SMK Kemabong	SMK Kemabong	Roundabout
		Kemabung	Kemabung District	Roundabout