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Ig heavy chain V-III region VH26 is a protein that in humans is encoded by the IGHV@ gene.[1][2][3]
IGHV is the immunoglobulin heavy chain variable region genes; in B-cell neoplasms like chronic lymphocytic leukemia, mutations of IGHV are associated with better responses to some treatments and with prolonged survival.[4]
See also
References
- ↑ Walter MA, Dosch HM, Cox DW (Aug 1991). "A deletion map of the human immunoglobulin heavy chain variable region". J Exp Med. 174 (2): 335–49. doi:10.1084/jem.174.2.335. PMC 2118905. PMID 1649888.
- ↑ Schroeder HW Jr; Walter MA; Hofker MH; Ebens A; Willems van Dijk K; Liao LC; Cox DW; Milner EC; Perlmutter RM (Dec 1988). "Physical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elements". Proc Natl Acad Sci U S A. 85 (21): 8196–200. Bibcode:1988PNAS...85.8196S. doi:10.1073/pnas.85.21.8196. PMC 282394. PMID 3141924.
- ↑ "Entrez Gene: IGHV@ immunoglobulin heavy variable group".
- ↑ Forconi F, Sozzi E, Cencini E, et al. (November 2009). "Hairy cell leukemias with unmutated IGHV genes define the minor subset refractory to single agent cladribine and with more aggressive behavior". Blood. 114 (21): 4696–4702. doi:10.1182/blood-2009-03-212449. PMID 19667403.
Further reading
- Matsuda F, Shin EK, Hirabayashi Y, et al. (1990). "Organization of variable region segments of the human immunoglobulin heavy chain: duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segments". EMBO J. 9 (8): 2501–6. doi:10.1002/j.1460-2075.1990.tb07429.x. PMC 552279. PMID 2114977.
- Cherif D, Berger R (1991). "New localizations of VH sequences by in situ hybridization with biotinylated probes". Genes Chromosomes Cancer. 2 (2): 103–8. doi:10.1002/gcc.2870020205. PMID 2126193. S2CID 22489747.
- Toyonaga B, Yoshikai Y, Vadasz V, et al. (1986). "Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain". Proc. Natl. Acad. Sci. U.S.A. 82 (24): 8624–8. doi:10.1073/pnas.82.24.8624. PMC 390970. PMID 3866244.
- Matthyssens G, Rabbitts TH (1981). "Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region". Proc. Natl. Acad. Sci. U.S.A. 77 (11): 6561–5. doi:10.1073/pnas.77.11.6561. PMC 350325. PMID 6450418.
- Mariette X, Tsapis A, Brouet JC (1993). "Nucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin-associated glycoprotein". Eur. J. Immunol. 23 (4): 846–51. doi:10.1002/eji.1830230412. PMID 7681398. S2CID 38756102.
- Boursier L, Su W, Spencer J (2003). "Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain variable gene segments". Mol. Immunol. 39 (16): 1025–34. doi:10.1016/S0161-5890(03)00033-6. PMID 12749909.
- Nakamura N, Nakamura S, Yamaguchi M, et al. (2005). "CD5+ diffuse large B-cell lymphoma consists of germline cases and hypermutated cases in the immunoglobulin heavy chain gene variable region". Int. J. Hematol. 81 (1): 58–61. doi:10.1532/IJH97.04119. PMID 15717690. S2CID 22639228.
- Suárez E, Magadán S, Sanjuán I, et al. (2006). "Rearrangement of only one human IGHV gene is sufficient to generate a wide repertoire of antigen specific antibody responses in transgenic mice". Mol. Immunol. 43 (11): 1827–35. doi:10.1016/j.molimm.2005.10.015. PMID 16343622.
- Balogh Z, Reiniger L, Deák L, et al. (2007). "IgVH gene mutation status and genomic imbalances in chronic lymphocytic leukaemia with increased prolymphocytes (CLL/PL)". Hematological Oncology. 25 (2): 90–5. doi:10.1002/hon.812. PMID 17410523. S2CID 19587621.
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