I80 or variation, may refer to:
- Interstate 80 (I-80), a U.S. highway
- AĆ©rotrain I80, a hovertrain
- Cascade Kasperwing I-80, an ultralight motorglider
- HMS Sherwood (I80), a WWII British Royal Navy Clemson-class destroyer
See also
- Watt/I-80 station, Sacramento, California
- 80i
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