He and She may refer to:
- He and She (album), by Wynton Marsalis
- He & She, American sitcom
- L'assoluto naturale, Italian film internationally released as He and She
- He and She (play), a 1920 play by Rachel Crothers
See also
- He-she, or shemale
- She/he, the gender-independent third person pronoun, in couplet form
- She and He (1963 film), a Japanese film
- She & Him, an American musical duo
- Him & Her, a British television show
- Her & Him, an adult film
- His and Hers (disambiguation)
- He, She and It, 1991 novel
- She (disambiguation)
- He (disambiguation)
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