Guilherme is a Portuguese given name, equivalent to William in English. The feminine form of this name is Guilhermina. Diminutive forms include Guilhermino. Vilma (Portuguese form of Wilma) is another female variant of the name.

Brazilian footballers

• Guilherme Alecsander Machado Guedes (born 1991), who last played for Marist
• Guilherme Alvim Marinato (born 1985), who currently plays for Lokomotiv Moscow
• Guilherme Augusto Vieira dos Santos (born 1995), forward
• Guilherme Borges (born 1999), midfielder
• Guilherme Camacho (born 1990), who currently plays for Corinthians
• Guilherme de Cássio Alves (born 1974), retired striker
• Guilherme Conceição Cardoso (born 1983), who is currently on loan to Vitória, from Cruzeiro
• Guilherme Costa Marques (born 1991), who currently plays for Legia Warsaw
• Guilherme Finkler (born 1985), who currently plays for Wellington Phoenix FC
• Guilherme Haubert Sityá (born 1990), left back
• Guilherme Lopes de Almeida (born 2002), left back
• Guilherme Mascarenhas Santana (born August 1990), midfielder
• Guilherme Mendes Ribeiro (born 2000), forward
• Guilherme Milhomem Gusmão (born 1988), who currently plays for Atlético Mineiro
• Guilherme Oliveira Santos (born 1988), who currently plays for Valladolid
• Guilherme de Paula Lucrécio (born 1986), who currently plays for Milsami Orhei
• Guilherme do Prado (born 1981), who last played for Chicago Fire
• Guilherme Schettine Guimarães (born 1995), who currently plays for Santa Clara
• Guilherme Siqueira (born 1986), retired Brazilian left back
• Guilherme Soares Guedes de Freitas (born 1999), who currently plays for Grêmio
• Guilherme Teixeira (born 1992) Brazilian footballer
• Guilherme Vinícius Quichini dos Santos (born 1993), who currently plays for Famalicão

Other

• Guilherme de Brito
• Guilherme Berenguer, Brazilian TV actor
• Guilherme Weber
• Guilherme Posser da Costa, prime minister of São Tomé and Príncipe
• Guilherme Samaia, Brazilian racing driver