Sai Joshi is a young and outspoken girl, living with her father Inspector Kamal Joshi, in Gadchiroli. She aspires to become a doctor and dreams to study MBBS at the Nagpur Medical College. In Nagpur, Virat Chavan becomes an officer and is posted at Gadchiroli. The local politician's son and goon, Jagtap, falls into a one-sided love with Sai and harasses her. Jagtap tries to kill Kamal in order to marry Sai. On topping 12th exam in Maharashtra state, Sai requests her father to take retirement and move to Nagpur. Virat joins his posting in Gadchiroli. Virat's car splashes mud on Sai which makes Sai dislike him. Further, Virat asks Kamal to postpone his VRS on stage. Kamal accepts his senior officer Virat's order which makes Sai angry. Virat and Pakhi become infatuated with each other, but the Chavan family selects Pakhi as Samrat's bride. In order to stay close to Virat, Pakhi marries Samrat, and Virat promises Pakhi not to replace her with any other girl. Pakhi confesses her love to Virat, which Samrat overhears, leading him to leave for duty, heartbroken.

Kamal Joshi takes the bullet to save Virat from Jagtap's shot which Sai witnesses. On his deathbed, Kamal asks Virat to take care of Sai. Sai then attempts suicide. After Kamal's funeral, villagers pressure Virat to marry orphaned Sai. Sai requests Virat to decline the marriage proposal and reminds him about Pakhi. Virat proposes a compromise marriage and unwillingly, Sai agrees to it. During the marriage, Virat reminds Sai to not expect any husbandly love and support from him as he already made a promise to Pakhi. Sai also makes it clear that she will leave their marriage once she completes her MBBS. Pakhi is upset by Virat and Sai's marriage, but Virat assures her by disclosing the marriage's details. The Chavan family, except for a few of the members and Virat's mother Ashwini, refuses to accept Virat and Sai's marriage as Sai is not from an upper class, Shahānnau Kule Maratha, like Pakhi. The Chavan family humiliates Sai by name-calling, defaming Kamal's death and his upbringing except for Ashwini, Virat's aunt Shivani, and Virat's cousins Devyani and Mohit who support Sai in the house.

Pakhi and the Chavan family humiliate Sai and ask Sai to apologize to Pakhi. Sai has an emotional breakdown due to constant bullying and harassment and agrees with their claim of calling herself incompetent and unfit to be in the Chavan family. Ninad's childhood dream is realized when Sai surprises him with a Harmonium, which Sai bought with her scholarship money. Ninad is speechless and accepts Sai. Pakhi traps Ajinkya to meet an unwell Sai in the bedroom and the Chavan family sees Pakhi's action but remains mute. Virat gets angry and harms Ajinkya physically and questions Sai's character. Sai feels hurt and leaves the house but is hit a by car. Virat apologizes to Sai by crying in front of Kamal's photo and she forgives him.

Virat plans a trip to Mahabaleshwar to celebrate their marriage anniversary. But he lies to Sai and the Chavan family that this trip is an official one. The Chavan family sympathizes with Pakhi. Virat narrates a fake love story to Sai, but the Yoga instructor interrupts them and speaks about Virat-Pakhi's love story. Sai becomes agitated as she thinks Virat was telling Pakhi and his love story which could not be completed due to her. They argue over their anniversary celebration and Sai leaves. Virat is hurt by Sai's behavior and seeks vengeance.

Pakhi hosts a Pooja and invites the Whole family but Sai refuses to attend as she knows Pakhi is just pretending to be with Samrat. Virat instructs Sai to attend Pooja instead of going to college Sai becomes adamant. Virat locks Sai in the room to prevent her from attending college. Sai leaves the house, then has an accident and is hospitalized. She later returns home. Sai and Virat restart their relationship as friends, but Pakhi loves him too.

On Diwali, Sai realizes that she has feelings for Virat. Sai decides to confess her feelings to Virat but He gets an order to go for a secret operation in the Naxalite area and departs. Virat and Shruti (wife of Naxalite, but she is not aware of her husband's connection to Naxalite) flee from the jungle after shooting a bullet at his best friend Naxalite Sada. Virat introduces Shruti as his wife in a hotel to protect her from the police and Mohit catches them. Police inform Virat that Sada's dead body is missing but Virat ignores it. Mohit reveals to the family that Virat was with Shruti in a hotel room as Mr. and Mrs. Chavan. This upsets Sai, and she pleads that the matter is clarified, but Virat ignores her. Virat spends much time with Shruti because she is pregnant, and she should not be introduced directly to anyone.

The police department suspends Virat for bigamy. To save Virat's job and reputation, Sai asks for a divorce and submits backdated divorce papers to the police department. So, they ask him to rejoin duty. Sada is still alive and learns of Shruti's affair with Virat, so he kidnaps Sai and asks Shruti to return. Virat is injured in a landmine blast while rescuing Sai and the police arrest Shruti and Sada for their crimes. Sai arranges a life-saving injection for Virat, and he regains consciousness. But he blames Sai for his condition and requests that the police release Shruti from all charges.

Sai returns to Chavan Niwas during Holi. The Chavan family supports Pakhi when she suggests throwing Sai into the Holi fire to be rid of her. On Holi, Sai brings Virat to the Holi function. The next day, Sai reads a letter from Shivani's ex-fiancé Rajeev. He tells Sai about feeling guilty after leaving Shivani and tells her that he only loved Shivani. Virat sees him and imprisons him. Sai informs Shivani that Rajeev feels guilty after leaving her and wants to patch up. The two women visit Rajeev in jail and Shivani forgives Rajeev.

Later he informs Sai that he lied to Bhavani about their future and encourages Sai to continue her internship, hiding from the family. The family realizes Virat's lie and the family's males support Sai. Soon Sai is revealed to be pregnant while Pakhi falls for Samrat. However, Jagtap kidnaps Sai and in his attempt to save her, Samrat is run over by Jagtap leading to his death. Pakhi blames Sai for the same and curses her due to which she suffers a miscarriage and becomes incapable of conceiving. Sai and Virat hire a woman named Geeta to carry their child by becoming his surrogate mother but Pakhi manipulates the woman and becomes the surrogate mother of the baby to get close to Virat. She blackmailed Sai by traveling to Mahabaleshwar during her pregnancy time without informing anyone and standing on the peak of the mountain and started blackmailing by putting conditions in front of Virat and Sai that if Sai promised Pakhi that she would not come close to her and only Virat will take care of her during the whole pregnancy. Later, Sai is unwell and The entire family feels that Sai is pregnant. Sai did the pregnancy test but the result came negative.

6 months later

At the baby shower, Pakhi challenges Sai that she will not hand over the baby after its birth, and with the help of the baby, she will enter Virat's life. She also threatens Sai that if she informed the same to others she will refuse to accept. Sai decides to keep quiet until delivery as she doesn't want chaos in the family, and she is more concerned about her unborn baby's health. Soon Pakhi feels labor pain at that movement no one is home, and Nagpur is having disastrous rain. Somehow Virat reaches home and does delivery on the instructions of Sai. The moment when Sai holds her child, she decides to forgive Pakhi and asks her to do the same and wants a fresh relationship. But Pakhi does a drama of suicide, and unwillingly, the family members take away Vinayak from Sai and give him to Pakhi. Now Sai is on a mission to find the truth, and within 15 days, she finds all evidence that proves that Pakhi manipulated Geeta and sent goons to attack Sai so she can't reach Geeta.

7 years later

Sai gives birth to a girl, Savi, raises her alone in Kankavli along with Usha, runs a school for housewives, and dreams of building a hospital in that place. Vinayak, Virat's adopted son whom he brought from an orphanage during a mission, goes camping and meets Sai and Savi and becomes their friend. Virat goes to Kankavli to surprise Vinayak. MLA Gulabrao, who opposes the idea of Sai's school, continuously conspires against Sai and attempts to kidnap Savi, but Virat saves her and drops her at her house.

Later, Virat and Vinayak return to Nagpur and are welcomed by Bhavani, who has become an MLA, and Pakhi, who now owns the family business and became Virat's second wife on the Chavan's insistence and come to a compromise with Virat that they will be husband and wife just for their namesake. Virat still remembers Sai and considers himself responsible for letting her go. Ashwini hates Sai for leaving Virat and tells him to forget her. Later, Bhavani and Ashwini plan a holiday for Pakhi and Virat, but they refuse to do so. Later, Virat and Vinayak go to Kankavli to meet Sai and Savi for Vinayak's treatment. Virat is shocked to see Sai alive and is angry with her and asks her about Savi. Later, Gulabrao insults Sai and questions her character and Virat beats him up. Later, Gulabrao's men kidnap Savi and attempt to kill her, but Virat saves her and ends up getting hurt. Pakhi urgently goes to Kankavli to meet Virat along with Mohit and is shocked to see Sai alive. Later, Virat and Pakhi return to Nagpur along with Vinayak and the family members get to know about Sai and Savi and break ties with Sai. Later, Vinayak's health deteriorates and Pakhi requests Sai to come to Nagpur for Vinayak's treatment. She agrees and comes to Nagpur and stays in a rented house along with Savi and Usha. Sai treats Vinayak and he can walk freely. Jagtap tells Virat about Savi being his daughter, and Virat stops Sai takes Savi from her, and gets her arrested.

The bus wrecks, and Pakhi gets severely injured. The doctors declare Pakhi dead, but Sai revives her and operates on her successfully. Pakhi is irked from Virat. Virat later accepts Pakhi as his wife and starts afresh. Later, Bhavani sends Virat and Pakhi on a honeymoon trip. Over there, Virat meets a couple, and they reveal that a few years ago when they were going to Gadhchiroli from Nagpur by bus, their bus meets an accident. Virat decided to find his lost son.

Sai takes Savi and Vinayak to Lonavla for an outing and meets Sahiba Monga, an artist during a social gathering and tells her story to her. Sai gets a job in a hospital in Nagpur and meets Sahiba again and work together. Later, a patient kidnaps Savi and Vinayak and keeps them in his custody. On hearing this, Pakhi falls unconscious and her health deteriorates. Sahiba, Sai, and Virat rescue them and Saheba goes back to Ludhiana. Virat discovers that Vinayak is his long-lost son which he adopted a long time ago. Pulkit tells the family that Pakhi's uterus has to be removed else she will die. Virat agrees to it and Pulkit and Sai save her life. Pakhi is devastated on hearing that her uterus was removed and she can never conceive. Later, Shivani reveals to the family that she is pregnant for 3 months. Bhavani hurls a taunt at her and Shivani leaves the family and breaks ties with everyone forever.

Pakhi files a case against Pulkit and Sai for removing her uterus but Pakhi loses the case. Later, Vinayak reunites with Sai and Sai plans to leave the house. Later, Virat goes on a mission but gets shot. Sai arrives there and Virat confesses his love for her. Sai fears that she will be the reason for breaking Pakhi's married life and decides to leave Virat forever. Virat locks her up in the house but Sai escapes. Virat goes behind her and finally meets Sai in a public gathering in which Bhavani was the chief guest. Virat confesses his love in public and as the public forces her, Sai agrees to marry him. Ashwini tells Sai to marry Satya. Sai tells Satya to marry her, and both marry, and Virat is left heartbroken. Pakhi realizes that Virat had never loved her and leaves him for good. It is revealed that Amba was Bhavani's sister who ran away with a person in the past and later that person left her while she was pregnant. Sai and Virat get closer, and Satya gets irked because of their closeness. Later, it was revealed that Satya's father is Vijendra Ghatge who was Sai's father's colleague who had Last Stage Brain Tumour. Vijendra and Amba reunite and get married. Vijendra had undergone surgery, and the surgery was successful. Sai realizes that her marriage with Satya to fulfill the promise given to her son Vinayak and her ex-mother-in-law Ashwini that she will not be the reason for breaking Virat and Pakhi's marriage was of no use as they got separated anyway so she decides to tell the truth to Satya that she still loves Virat and can't be with him for the namesake. Satya proposes to Sai and before she could tell him her truth Satya collapses in front of her discovering that Satya's nerve got injured in an accident and his legs get paralyzed. Satya also realizes that Sai still loves Virat and asks her to return to Virat, but she refuses because she can't leave him in his bad days as he is now her responsibility. Sai consults the doctors, and they advise her to take Satya to Germany. Later, Sai visits Chavan's house for the last time and leave for the airport. Later, Ashwini and Bhavani decide to go to Mumbai with the entire family to go to Siddhivinayak Temple. Virat arrests a criminal Ramakant Pujari due to which his aides led by Bheema Pujari decide to teach the Police a lesson by hijacking a flight to Mumbai. Savi overhears their conversation and tells it to Virat and Sai.

14 years later

Savi has grown up to become a confident and headstrong, yet a good-hearted and honourable woman, and is the most popular student in the college and wants to become an IAS officer while Vinayak is studying to become a doctor by pursuing an MBBS degree in Pune. Bhavani decides to get Savi's marriage done as soon as possible. The Chavans are now not well-off as Bhavani has sold off the old house to fund Vinayak's college education and has now relocated to Ramtek. Ninad is afflicted with alzheimers, and the Chavans keep him away from the fact that Sai and Virat are no longer alive.

Meanwhile in Pune, a bond of mutual admiration forms between the managing director of Bhosale Institute of Excellence, Ishaan Bhosle, and his student Reeva Marathe, who were childhood friends. Ishaan suffers from a traumatic past as his mother, Isha had left him while he was young to take care of her ailing parents. Ishaan misunderstands the situation and thinks that she had left him to advance in her career which has made Ishaan hostile towards her. Isha is also a teacher and a mentor to Savi, and motivates her to take part in the debate competition held in Nagpur to get a scholarship from Bhosale Institute of Excellence, which will bring her a step closer to becoming an IAS. Savi wins the scholarship, but to her dismay, Bhavani has already arranged a marriage set up for her. Bhavani disregards her career ambitions and asks her to marry Samruddh Latkar.

Seeing Ishaan and Reeva's growing closeness, Yashwant proposes their marriage to Reeva's father Swanand and he agrees, but Reeva's mother, Swati is apprehensive of this relationship. On the engagement day, Swati blackmails Reeva that she will commit suicide if Reeva doesn't go to London for her further studies as she fears that she will not be able to progress in her career once she gets married. Reeva agrees to do so and Ishaan, unable to heal from his mother, Isha's betrayal, he breaks his engagement with Reeva.

An apprehensive Savi informs Isha about her forced marriage. Sensing trouble, Isha seeks to learn about Samruddh Latkar. In a shocking disclosure, it is revealed that Samruddh is a drunkard and druggist womanizer and his father Mandar Latkar is a don in Ramtek. Isha informs Savi about this. Savi, on learning the truth, informs Ashwini, Ninad, and Harini. They ask Savi to run away from the marriage. Savi runs away from the marriage to Pune with the help of Isha, in the hope of getting admission to the Bhosale Institute. Bhavani disowns Savi after she gets to know that Isha and the rest of the family helped her run away. After facing many trials and tribulations, Savi with the help of Isha gets admission to the Bhosale Institute.

Savi faces a lot of problems in the college as she gets bullied by Dhurva and her gang and gets no support from Ishaan. Savi was also almost molested by Harini's abusive husband, Kiran. Isha comes to Bhosale Institute for the inspection and discovers illegal activities that are happening in the college. Isha gets shot by a goon sent by Vinayak and Mandar. Mandar gets caught and is arrested and Savi breaks ties with Vinayak.

Harini is pregnant but Kiran beats her so badly that she suffers a miscarriage and cannot become a mother again. Savi beats up Kiran and gets him arrested with the help of ACP Bajirao, Shantanu's old student. Kiran's parents call Bhavani to Pune and Savi tells the entire truth to her. Bhavani regrets her actions and says that Savi was right to arrest Kiran. Later, Mandar and Samruddh escape from Ramtek and come to Bhosale's house in Pune under the name of Mr. Patil and Sam Patil for a marriage proposal with Dhurva. They want an alliance with the Bhosales to pay off all their debts.

Savi reveals Mandar and Samruddh's true face to the Bhosales on Dhurva's engagement, but everyone arrogantly refuses to believe her. However, Ishaan supports her and she finally manages to make Mandar accept all his crimes. ACP Bajirao arrives to arrest them. Everyone is grateful to Savi for saving Dhurva's life, but Dhurva refuses to believe Savi and is crazy for Samruddh. The family blames Surekha for not doing a proper background check and for nearly ruining Dhurva's life. Surekha teams up with Dhurva to get revenge on Isha and Savi.

Reeva returns from London, expressing her feelings to Ishaan, who harshly rejects her. Harini tells Savi about Ninad's deteriorating health. Bhavani and Vinayak bring Ninad to Pune for his treatment. Meanwhile, Reeva applies for a job as an Assistant Professor at Bhosale Institute but is denied entry to the college. Isha arrives as an interview panel member from the Education Board. With the help of Savi, Reeva enters the college and Ishaan gets irritated after seeing her and tells her to go out but Isha, unaware of Ishaan and Reeva's relation, intervenes and allows her to give the interview. Reeva gave the interview after which Shantanu tells Isha about them. Isha feels guilty for hurting Ishaan and warns Reeva not to hurt Ishaan. Later, Reeva gets the job and Savi and Reeva become very good friends. Ishaan tells the newly appointed employees that they are on a probation period for 3 months after which he will decide based on their performance to be a permanent employee.

Ninad gets a head injury, due to which he has temporary memory loss. With the help of Ishaan, Ninad gets his memory back. Ishaan gets to know about Ninad from Savi and tells the doctor to do the surgery free of cost. The surgery is successful and Savi thanks Ishaan. Bhavani apologizes to Savi for her actions and supports her dreams. On Isha's birthday, Savi gets to know about her story. Savi decides to enact a play on the college fest based on Ishaan and Isha's story in which she plays the role of Isha and Reeva plays the role of Surekha. During the play, It is revealed that when Ishaan was 6 years old, Isha's brother died in an accident and Isha decided to move into her parent's house along with Ishaan and Shantanu but Surekha and Yashwant were against this. Shantanu refused to come with her and Surekha was against Isha for taking Ishaan along with her. When she was leaving, Surekha ordered Isha to leave the house without Ishaan. Isha requested Surekha and Yashwant but was helpless without getting support from Shantanu and left the house and ever since Ishaan has hated her to the core. After the play, Ishaan, Reeva, and the rest get to know that the play was based on Ishaan's childhood and they get furious with Savi and Surekha slaps her. The whole family faces the media trial, but Ishaan faces it and accepts Surekha as his mother.

Despite Shantanu confirming Isha's departure, due to the family opposition to be true, Ishaan still remains unreasonably angry, and hostile towards both Isha and Savi, when in fact, he should actually be angry, and hostile towards Yashwant and Surekha not only for their misdeeds, but also for ruining his life and for separating him from his mother. Later, Savi criticizes Ishaan for his behavior, reminding him that he is Isha's son and that his unjustified anger, hatred and hostility towards his mother make him an unworthy son, he is visibly hurt by what she says, because deep down Ishaan knows that, he can't be angry with or hate Isha anymore after knowing the truth.