Frederick Alt
Other namesFred Alt
Alma mater
Scientific career
Institutions
Doctoral studentsKaren M. Frank

Frederick W. Alt is an American geneticist. He is a member of the Immunology section of the National Academy of Sciences and a Charles A. Janeway Professor of Pediatrics, and Professor of Genetics at Harvard Medical School.[1] He is the Director of the Program in Cellular and Molecular Medicine at the Boston Children's Hospital.[2] He is a Howard Hughes Medical Institute investigator, since 1987.

Career

Alt completed his undergraduate studies at Brandeis University, graduating in 1971.[3] He then went on to earn a Ph.D. in Biology from Stanford University in 1977 while under the research direction of Robert Schimke. He performed his postdoctoral work in David Baltimore's laboratory at Massachusetts Institute of Technology (MIT).[4] From 1982 to 1991 he was on the faculty at Columbia University and then moved to Harvard Medical School.[5]

Alt's research interest is in maintenance of genome stability in cells of the mammalian immunological system, particularly antigen receptor variable region gene assembly in developing B and T lymphocytes, immunoglobulin heavy chain class switch recombination (CSR), and somatic hypermutation in activated mature B lymphocytes.[1]

Personal life

Alt is the son-in-law of the organic chemist, Koji Nakanishi, who served as Centennial Professor of Chemistry and chair of the Chemistry Department at Columbia University.[6]

Alt is also the father of the chef and food writer, J. Kenji López-Alt.[7]

Awards, memberships and honors

He has received many awards, this is a select list:

The Cancer Research Institute of New York gives an annual prize in his honor, the Frederick W. Alt Award for New Discoveries in Immunology.

Alt is a member of:

References

  1. 1 2 Dana-Farber profile
  2. ↑ "How new loops in DNA packaging help us make diverse antibodies". phys.org. Retrieved November 14, 2019.
  3. 1 2 "Pioneering geneticist Frederick Alt '71 wins 44th Rosenstiel Award". BrandeisNOW. Retrieved November 14, 2019.
  4. ↑ "Alt Laboratory". www.childrenshospital.org. Retrieved December 29, 2022.
  5. ↑ "Children's Hospital bio". Archived from the original on January 20, 2018. Retrieved September 10, 2011.
  6. ↑ "J. Kenji López-Alt: Seattle's Famous Japanese American Cooking Star". The North American Post. September 23, 2022. Archived from the original on October 6, 2022. Retrieved December 9, 2022.
  7. ↑ Robertson, Blair Anthony (2015). "Science becomes delicious in 'The Food Lab'". The Sacramento Bee. Archived from the original on December 16, 2015. Retrieved November 13, 2019. His father, Frederick Alt, is a professor at Harvard Medical School
  8. ↑ "Laureates". Novartis Prizes for Immunology. August 29, 2018. Archived from the original on August 29, 2018. Retrieved November 14, 2019.
  9. ↑ "CRI Announces Winner of 2009 Frederick Alt Award for New Discoveries in Immunology". Cancer Research Institute. Retrieved November 14, 2019.
  10. ↑ Scully, Peter; Zhao, Jie; Ba, Sujuan (February 3, 2016). "Frederick W. Alt received the 2015 Szent-Györgi Prize for Progress in Cancer Research". Chinese Journal of Cancer. 35: 17. doi:10.1186/s40880-015-0075-x. ISSN 1000-467X. PMC 4741029. PMID 26843073.
  11. ↑ "AAI-BioLegend Herzenberg Award". The American Association of Immunologists, Inc. (AAI).
  12. ↑ "AAI Career Awards". Immunology 2019. Retrieved November 14, 2019.
  13. ↑ Paul Ehrlich and Ludwig Darmstaedter Prize 2023
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