Frank Greene may refer to:
- Frank L. Greene (1870–1930), United States representative and senator from Vermont
- Frank David Greene (born 1963), American trumpet player author, and speaker
- Frank S. Greene, American scientist and venture capitalist
- Frank Greene (singer) (born 1879), English baritone in Australia
See also
- Francis Vinton Greene (1850–1921), United States Army general
- Frank Green (disambiguation)
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