Francis de Sales (1567–1622) was the bishop of Geneva.

Francis de Sales or Saint Francis de Sales may also refer to:

• Francis De Sales (actor) (1912–1988), American actor
• Cathedral of St. Francis de Sales (disambiguation)
• St Francis de Sales College, Mount Barker, South Australia
• St. Francis de Sales' Church (disambiguation)
• St. Francis de Sales High School (disambiguation)
• St. Francis De Sales Regional Catholic School, Herkimer, New York, United States
• St Francis de Sales Regional College, Leeton, New South Wales, Australia
• St Francis de Sales School, Dhemaji, Assam, India
• St Francis de Sales, Hampton Hill and Upper Teddington, a Roman Catholic church in Hampton Hill, Richmond upon Thames, London

See also

• St. Francis (disambiguation)