Francis Radclyffe may refer to:
- Francis Radclyffe, 1st Earl of Derwentwater and 3rd Baronet (1625–1697)
- Sir Francis Radclyffe, 1st Baronet of the Radclyffe Baronets, of Derwentwater
See also
- Frances Radclyffe (disambiguation) for the female version of the name
- Francis Ratcliffe, zoologist
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