Fotopoulos (Greek: Φωτόπουλος) or Photopoulos (sometimes for female persons it becomes: Fotopoulou or Photopoulou) is a Greek surname. Notable people with the surname include:

• Danielle Fotopoulos (born 1976), soccer player, US women's national soccer team
• George Fotopoulos, former head coach of the LSU women's soccer team
• Helen Fotopulos, Montreal city councillor
• James Fotopoulos (born 1976), American independent filmmaker
• Mimis Fotopoulos (1913-1986), Greek actor
• Takis Fotopoulos (born 1940), Greek political writer and editor
• Vassilis Photopoulos (1934-2007), Greek painter and film director