FKBP8

FKBP8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AWG, 2D9F, 2F2D, 2MF9, 3EY6
Identifiers
Aliases	FKBP8, FKBP38, FKBPr38, FK506 binding protein 8, FKBP prolyl isomerase 8
External IDs	OMIM: 604840 MGI: 1341070 HomoloGene: 7720 GeneCards: FKBP8
Gene location (Human)
Chr.	Chromosome 19 (human)
End	18,544,077 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	70,987,978 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; cingulate gyrus; ; right uterine tube; ; popliteal artery; ; gastric mucosa; ; tibial nerve; ; prefrontal cortex; ; right coronary artery; ; thoracic aorta; ; ascending aorta;
	Top expressed in
	superior frontal gyrus; ; spermatocyte; ; lip; ; entorhinal cortex; ; yolk sac; ; gallbladder; ; cerebellar cortex; ; superior surface of tongue; ; spermatid; ; thymus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	FK506 binding; isomerase activity; peptidyl-prolyl cis-trans isomerase activity; metal ion binding; protein binding; identical protein binding; disordered domain specific binding;
Cellular component	integral component of membrane; membrane; mitochondrial membranes; integral component of endoplasmic reticulum membrane; mitochondrial envelope; mitochondrion; endoplasmic reticulum; cytosol; cytoplasm; protein-containing complex;
Biological process	apoptotic process; intracellular signal transduction; multicellular organism growth; cell fate specification; negative regulation of apoptotic process; regulation of BMP signaling pathway; neural tube development; positive regulation of BMP signaling pathway; regulation of gene expression; smoothened signaling pathway; camera-type eye development; dorsal/ventral neural tube patterning; viral process; dorsal/ventral pattern formation; chaperone-mediated protein folding; protein peptidyl-prolyl isomerization; negative regulation of protein phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	23770
	14232
	ENSG00000105701
	ENSMUSG00000019428
	Q14318
	O35465
	NM_001308373; NM_012181
	NM_001111066; NM_001199631; NM_010223
	NP_001295302; NP_036313; NP_001295302.1
	NP_001104536; NP_001186560; NP_034353
	Wikidata
View/Edit Human	View/Edit Mouse

FK506-binding protein 8 is a protein that in humans is encoded by the FKBP8 gene.^[5]^[6]

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105701 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019428 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lam E, Martin M, Wiederrecht G (Sep 1995). "Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs". Gene. 160 (2): 297–302. doi:10.1016/0378-1119(95)00216-S. PMID 7543869.
1 2 "Entrez Gene: FKBP8 FK506 binding protein 8, 38kDa".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Pedersen KM, Finsen B, Celis JE, Jensen NA (1999). "muFKBP38: a novel murine immunophilin homolog differentially expressed in Schwannoma cells and central nervous system neurons in vivo". Electrophoresis. 20 (2): 249–55. doi:10.1002/(SICI)1522-2683(19990201)20:2<249::AID-ELPS249>3.0.CO;2-F. PMID 10197430. S2CID 23007045.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Shirane M, Nakayama KI (2003). "Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis". Nat. Cell Biol. 5 (1): 28–37. doi:10.1038/ncb894. PMID 12510191. S2CID 11653096.
Rosner M, Hofer K, Kubista M, Hengstschläger M (2003). "Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38". Oncogene. 22 (31): 4786–98. doi:10.1038/sj.onc.1206776. PMID 12894220.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
Bulgakov OV, Eggenschwiler JT, Hong DH, et al. (2004). "FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues". Development. 131 (9): 2149–59. doi:10.1242/dev.01122. PMID 15105374. S2CID 8203913.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Kang CB, Tai J, Chia J, Yoon HS (2005). "The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38)". FEBS Lett. 579 (6): 1469–76. doi:10.1016/j.febslet.2005.01.053. hdl:10356/95126. PMID 15733859. S2CID 19114701.
Weiwad M, Edlich F, Erdmann F, et al. (2005). "A reassessment of the inhibitory capacity of human FKBP38 on calcineurin". FEBS Lett. 579 (7): 1591–6. doi:10.1016/j.febslet.2004.12.098. PMID 15757646. S2CID 12995306.
Edlich F, Weiwad M, Erdmann F, et al. (2005). "Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin". EMBO J. 24 (14): 2688–99. doi:10.1038/sj.emboj.7600739. PMC 1176465. PMID 15990872.
Kang CB, Feng L, Chia J, Yoon HS (2005). "Molecular characterization of FK-506 binding protein 38 and its potential regulatory role on the anti-apoptotic protein Bcl-2". Biochem. Biophys. Res. Commun. 337 (1): 30–8. doi:10.1016/j.bbrc.2005.09.023. hdl:10356/94816. PMID 16176796.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105701 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019428 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7543869-5] Lam E, Martin M, Wiederrecht G (Sep 1995). "Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs". Gene. 160 (2): 297–302. doi:10.1016/0378-1119(95)00216-S. PMID 7543869.

[entrez-6] 1 2 "Entrez Gene: FKBP8 FK506 binding protein 8, 38kDa".

[1]

[2]

[3]

[4]

[5]

[6]

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Further reading