FGF12

FGF12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Q1U, 4JQ0
Identifiers
Aliases	FGF12, FGF12B, FHF1, fibroblast growth factor 12, EIEE47, DEE47
External IDs	OMIM: 601513 MGI: 109183 HomoloGene: 10874 GeneCards: FGF12
Gene location (Human)
Chr.	Chromosome 3 (human)
End	192,767,764 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	28,571,820 bp
RNA expression pattern
	Top expressed in
	pons; ; right ventricle; ; middle temporal gyrus; ; prefrontal cortex; ; superior frontal gyrus; ; dorsolateral prefrontal cortex; ; vena cava; ; postcentral gyrus; ; Brodmann area 23; ; Brodmann area 46;
	Top expressed in
	superior frontal gyrus; ; medial dorsal nucleus; ; facial motor nucleus; ; medial geniculate nucleus; ; pontine nuclei; ; anterior horn of spinal cord; ; lateral geniculate nucleus; ; medial vestibular nucleus; ; cerebellar cortex; ; substantia nigra;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	sodium channel regulator activity; heparin binding; transmembrane transporter binding; fibroblast growth factor receptor binding; protein binding; growth factor activity;
Cellular component	nucleus; intracellular anatomical structure; extracellular space;
Biological process	negative regulation of cation channel activity; adult locomotory behavior; cell-cell signaling; cardiac muscle cell action potential involved in contraction; regulation of membrane depolarization; nervous system development; fibroblast growth factor receptor signaling pathway; JNK cascade; heart development; neuromuscular process; regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; regulation of sodium ion transmembrane transport; signal transduction; chemical synaptic transmission; regulation of voltage-gated sodium channel activity; regulation of neuronal action potential; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	2257
	14167
	ENSG00000114279
	ENSMUSG00000022523
	P61328
	P61329
	NM_004113; NM_021032; NM_001377292; NM_001377293; NM_001377294
	NM_001276419; NM_001276420; NM_010199; NM_183064; NM_001357064
	NP_004104; NP_066360; NP_001364221; NP_001364222; NP_001364223
	NP_001263348; NP_001263349; NP_034329; NP_898887; NP_001343993
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor 12 is a protein that in humans is encoded by the FGF12 gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000114279 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022523 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Oct 1996). "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development". Proc Natl Acad Sci U S A. 93 (18): 9850–7. Bibcode:1996PNAS...93.9850S. doi:10.1073/pnas.93.18.9850. PMC 38518. PMID 8790420.
↑ Liu Y, Chiu IM (Nov 1997). "Assignment of FGF12, the human FGF homologous factor 1 gene, to chromosome 3q29-->3qter by fluorescence in situ hybridization". Cytogenet Cell Genet. 78 (1): 48–9. doi:10.1159/000134625. PMID 9345906.
1 2 "Entrez Gene: FGF12 fibroblast growth factor 12".

Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
Kok LD, Tsui SK, Waye M, et al. (1999). "Cloning and characterization of a cDNA encoding a novel fibroblast growth factor preferentially expressed in human heart". Biochem. Biophys. Res. Commun. 255 (3): 717–21. doi:10.1006/bbrc.1999.0178. PMID 10049777.
Schoorlemmer J, Goldfarb M (2001). "Fibroblast growth factor homologous factors are intracellular signaling proteins". Curr. Biol. 11 (10): 793–7. doi:10.1016/S0960-9822(01)00232-9. PMC 3216481. PMID 11378392.
Liu CJ, Dib-Hajj SD, Renganathan M, et al. (2003). "Modulation of the cardiac sodium channel Nav1.5 by fibroblast growth factor homologous factor 1B". J. Biol. Chem. 278 (2): 1029–36. doi:10.1074/jbc.M207074200. PMID 12401812.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Olsen SK, Garbi M, Zampieri N, et al. (2003). "Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs". J. Biol. Chem. 278 (36): 34226–36. doi:10.1074/jbc.M303183200. PMID 12815063.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Popovici C, Conchonaud F, Birnbaum D, Roubin R (2004). "Functional phylogeny relates LET-756 to fibroblast growth factor 9". J. Biol. Chem. 279 (38): 40146–52. doi:10.1074/jbc.M405795200. PMID 15199049.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000114279 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022523 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8790420-5] Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Oct 1996). "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development". Proc Natl Acad Sci U S A. 93 (18): 9850–7. Bibcode:1996PNAS...93.9850S. doi:10.1073/pnas.93.18.9850. PMC 38518. PMID 8790420.

[pmid9345906-6] Liu Y, Chiu IM (Nov 1997). "Assignment of FGF12, the human FGF homologous factor 1 gene, to chromosome 3q29-->3qter by fluorescence in situ hybridization". Cytogenet Cell Genet. 78 (1): 48–9. doi:10.1159/000134625. PMID 9345906.

[entrez-7] 1 2 "Entrez Gene: FGF12 fibroblast growth factor 12".

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[4]

[5]

[6]

[7]

References

Further reading