Yu Liang's regency

Initially, the officials were in charge together, but as Empress Dowager Yu became regent, Yu Liang became effectively the most powerful official in the administration. He changed from the lenient policies of Wang (who was prime minister during Emperor Ming's reign) to stricter applications of laws and regulations, which offended the officials accustomed to Wang's lenience. Further, he became apprehensive of the generals Tao Kan and Zu Yue—neither of whom was mentioned in the list of honors and promotions announced by Emperor Ming's will and believed that Yu had erased their names from the will—and Su Jun, who had allowed many criminals to join his army. In 326, he alienated public opinion by falsely accusing Sima Yang's brother Sima Zong (司馬宗) the Prince of Nandun of treason and killing him and deposing Sima Yang.

The Su Jun Disturbance

In 327, apprehensive of Su, Yu decided to try to strip his military command by promoting him to the minister of agriculture—a position that did not involve commanding troops. After initially hesitating, Su eventually refused and formed an alliance with Zu against Yu. Upon hearing this, Wen, whom Yu had made the governor of Jiang Province (江州, modern Jiangxi) to defend against Tao, the governor of Jing Province (荊州, modern Hubei), wanted to quickly move to help defend the capital Jiankang, as did the local forces to the east of the capital, but Yu declined all help, wanting Wen to remain in position against Tao and believing that he can defeat Su easily. Fearful that Yu would be defeated by Su, Wen headed toward the capital anyway. Before Wen arrived, Su was able to capture the capital in early 328 and take Emperor Cheng and Empress Dowager Yu hostage. Bian died in the battle, and Yu Liang was forced to flee to Wen. Su allowed his soldiers to pillage the capital, and officials and commoners alike had their possessions—as well as clothes—stripped by Su's army, which even seized Empress Dowager Yu's servant girls. Empress Dowager Yu, humiliated by Su and fearful of what was to come, soon died in anxiety.

Su organized a new government, with Wang Dao, whom Su respected, as the titular regent, but with Su himself in actual power. Meanwhile, Yu and Wen organized efforts to recapture the capital. Wen's cousin Wen Chong (溫充) suggested inviting Tao, a capable general with a sizable army, to be the supreme commander of the army. However, Tao, still resentful of Yu, initially refused. Eventually he relented and joined Wen and Yu. They advanced east toward Jiankang. In response, Su forcibly took Emperor Cheng to the fortress of Shitou and put him and his attendants under virtual arrest. Meanwhile, Wang was secretly ordering the commanderies to the east to rise against Su, and he eventually persuaded Su's general Lu Yong (路永) to defect with him to Wen and Tao's army as well. Xi also arrived with his forces from Guangling (廣陵, in modern Huai'an, Jiangsu).

The Su and anti-Su forces battled for months, indecisively, and despite the numeric advantage the anti-Su forces had, they were unable to prevail, leading Tao to at one point consider withdrawing. However, Wen was able to persuade him to stay and continuing the battles against Su. In the fall, during an assault on Shitou, the anti-Su forces initially suffered losses, but as Su was making a counterattack against them, he fell off his horse and was hit by spears. The anti-Su soldiers rushed him and decapitated him. Su's forces initially supported his brother Su Yi (蘇逸) as leader and continued to defend Shitou, but by early 329 were defeated.

In the aftermaths of Su Jun's defeat, with Jiankang having been heavily damaged by war, the top officials considered moving the capital to either Yuzhang (豫章, in modern Nanchang, Jiangxi) or Kuaiji (in modern Shaoxing, Zhejiang), but after Wang opposed, noting that Jiankang was in a better position to monitor the northern defenses against Later Zhao, the capital remained at Jiankang. Wen was requested to remain in Jiankang as regent, but he, believing that Emperor Ming intended Wang to serve that role, yielded the position to Wang. Meanwhile, Yu Liang, initially offering to resign all of his posts and go into exile, accepted a provincial governor post.

In light of his mother's death, the eight-year-old Emperor Cheng appeared to have been raised by his paternal grandmother, Lady Xun, from this point on.

Wang Dao's regency

In late 329, Wen Jiao died, and the general Guo Mo (郭默) soon assassinated his successor Liu Yin (劉胤) and seized Jing Province for himself. Wang Dao initially wanted to avoid another war and placated Guo, but Tao Kan and Yu Liang opposed, and their forces quickly converged on Jiang Province's capital Xunyang (尋陽, in modern Jiujiang, Jiangxi) in 330, killing Guo.

Meanwhile, during and after the Su Jun Disturbance, Jin forces in central China, without the central government's aid, were unable to hold their positions and eventually lost most of central China to Later Zhao. Key cities lost during this time included the old capital Luoyang, Shouchun (壽春, in modern Lu'an, Anhui), and Xiangyang (襄陽, in modern Xiangfan, Hubei), although Xiangyang was recaptured in 332. In 333, Jin also lost Ning Province (寧州, modern Yunnan and Guizhou) to Cheng Han (but regained it in 339).

As regent, Wang largely restored his earlier policy of lenience and lax enforcement of the laws, greatly stabilizing the political scene but also leading to the spreading of corruption and incompetence. Eventually, in 338, Yu Liang tried to persuade Xi Jian to join him in moving to depose Wang, but after Xi refused, Yu did not carry out his plan.

In 336, Emperor Cheng married his wife Empress Du. Both of them were 15.

In 337, Murong Huang, the Xianbei chief who had been a Jin vassal with the Jin-bestowed title of Duke of Liaodong, claimed the title of Prince of Yan notwithstanding Jin's failure to grant him that title, effectively declaring independence and establishing Former Yan, although Murong Huang continued to claim to be a Jin vassal.

In 339, Yu wanted to make a major attack against Later Zhao, hoping to recapture central China, and Wang initially agreed with him, but after opposition by Xi and Cai Mo, Emperor Cheng ordered Yu not to carry out the war plans. Wang died in the fall of that year, and was succeeded by his assistant He Chong (何充) and Yu Liang's younger brother Yu Bing (庾冰). Emperor Cheng let He and Yu Bing decide most important matters, but also appeared to start making some decisions of his own. Yu Bing and He tried to reform some of the problems with Wang's regency, but did not appear very effective at doing so.

Late reign

After Wang Dao's death, Yu Liang resumed his plans for a campaign against Later Zhao, and this brought a major response by Later Zhao's emperor Shi Hu in late 339. Later Zhao forces inflicted great damage on many Jin cities and bases north of the Yangtze and captured Zhucheng (邾城, in modern Huanggang, Hubei). Humiliated, Yu cancelled the plans for a northern campaign, and he died in early 340.

Also in 340, Murong Huang formally requested that he be granted the title Prince of Yan. After lengthy debates among key officials about whether Murong Huang was still a faithful vassal, Emperor Cheng himself ruled that the request be granted.

In spring 341, Empress Du died. Emperor Cheng would not create another empress.

Later that year, Emperor Cheng decreed that the refugees from northern and central China, who had fled south during the times of Emperor Huai and Emperor Min, who had retained household registrations according to their native commanderies, be henceforth registered with the commanderies that they were now living in. This pragmatic move allowed the local commanderies to have greater manpower and reduced redundancy in local administrations.

In summer 342, Emperor Cheng grew gravely ill. He had two young sons -- Sima Pi and Sima Yi, then still in cradles, by his concubine Consort Zhou. Yu Bing, fearful that the Yus would lose power if a young emperor were named, persuaded Emperor Cheng that in the face of the powerful enemy Later Zhao that an older emperor should be named. Emperor Cheng agreed and designated his younger brother, Sima Yue the Prince of Langya be his heir, despite He Chong's opposition. He issued an edict entrusting his sons to Yu Bing, He, Sima Xi (司馬晞), Prince of Wuling, Sima Yu, Prince of Kuaiji (both paternal uncles), and Zhuge Hui (諸葛恢). He died soon thereafter and was succeeded by Prince Yue (as Emperor Kang).