Durham is a surname. Notable people with the surname include:

• Bartlett S. Durham (1824–1859), American physician and the namesake of Durham, North Carolina
• Carl T. Durham (1892–1974) was an American politician who served as a member of the United States House of Representatives from North Carolina.
• David Anthony Durham (born 1969), American novelist
• Edward B. Durham (c. 1870 – c. 1930), American mining engineer and Professor
• Florence Margaret Durham (1869–1949), British geneticist
• Geoffrey Durham (born 1949), British comedy magician and actor
• Hugh Durham (born 1937), American college basketball coach
• Jim Durham (1947–2012), American sportscaster
• Jimmie Durham (1940–2021), American sculptor and poet
• John Durham (disambiguation), multiple people
• Judith Durham (1943–2022), Australian singer, member of The Seekers
• Leon Durham (born 1957), American baseball player
• Payne Durham (born 2000), American football player
• Philip Charles Durham (1763–1845), British admiral who fought at the Battle of Trafalgar
• Ray Durham (born 1971), American baseball player
• Rhea Durham (born 1978), American fashion model
• Ron Durham (1921–2021), Australian rules footballer
• Walter T. Durham (1924–2013), American historian
• Woody Durham (1941–2018), American radio announcer