De Medina is a surname. Notable people with the surname include:
- Bartolomé de Medina (theologian), Spanish theologian
- Eduardo Diez de Medina
- Federico Diez de Medina
- Juan de Medina
- Lucila Gamero de Medina
- Miguel de Medina
- Nathan de Medina, Belgian footballer
- Samuel de Medina
- Solomon de Medina
See also
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