Cardinale is a surname. Notable people with the surname include:
- Claudia Cardinale (born 1938), Tunisian-born Italian actress
- Gerald Cardinale (1934–2021), American politician
- Igino Eugenio Cardinale (1916–1983), Italian Roman Catholic archbishop and diplomat
- Lindsey Cardinale (born 1985), American singer
- Marco Cardinale (born 1973), Italian sports scientist and administrator
- Salvatore Cardinale (born 1948), Italian politician
- Tina Cardinale-Beauchemin (born 1966), American athlete
See also
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