CQB may refer to:
- Close-quarters combat, a close combat situation between multiple combatants involving ranged weapons
- Chandler Regional Airport, the FAA LID code CQB
- Chicom CQB, a suppressed bullpup submachine gun
- AA-12 CQB, a variant of an automatic combat shotgun Atchisson AA-12
- SWAT 3: Close Quarters Battle or SWAT3:CQB, a tactical shooter video game
- CQB (The Expanse), an episode of the American science fiction television series The Expanse
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