CDKN2C

CDKN2C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BU9, 1G3N, 1IHB, 1MX2, 1MX4, 1MX6
Identifiers
Aliases	CDKN2C, INK4C, p18, p18-INK4C, cyclin-dependent kinase inhibitor 2C, cyclin dependent kinase inhibitor 2C
External IDs	OMIM: 603369 MGI: 105388 HomoloGene: 966 GeneCards: CDKN2C
Gene location (Human)
Chr.	Chromosome 1 (human)
End	50,974,634 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	109,524,386 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; adipose tissue; ; spongy bone; ; abdominal fat; ; superficial temporal artery; ; right coronary artery; ; subcutaneous adipose tissue; ; left coronary artery; ; thymus; ; ganglionic eminence;
	Top expressed in
	spermatocyte; ; white adipose tissue; ; brown adipose tissue; ; subcutaneous adipose tissue; ; thymus; ; spermatid; ; seminiferous tubule; ; medial ganglionic eminence; ; intercostal muscle; ; hair follicle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; cyclin-dependent protein serine/threonine kinase inhibitor activity; protein kinase binding;
Cellular component	cytoplasm; cytosol; nucleus;
Biological process	cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; oligodendrocyte differentiation; negative regulation of phosphorylation; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; G1/S transition of mitotic cell cycle; negative regulation of G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	1031
	12580
	ENSG00000123080
	ENSMUSG00000028551
	P42773
	Q60772
	NM_078626; NM_001262
	NM_001301368; NM_007671
	NP_001253; NP_523240
	NP_001288297; NP_031697
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase 4 inhibitor C is an enzyme that in humans is encoded by the CDKN2C gene.^[5]^[6]^[7]

Function

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.^[7]

Interactions

CDKN2C has been shown to interact with Cyclin-dependent kinase 4^[5]^[8] and Cyclin-dependent kinase 6.^[5]^[8]^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000123080 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028551 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG, Xiong Y (January 1995). "Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function". Genes Dev. 8 (24): 2939–52. doi:10.1101/gad.8.24.2939. PMID 8001816.
↑ Blais A, Labrie Y, Pouliot F, Lachance Y, Labrie C (July 1998). "Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer". Biochem. Biophys. Res. Commun. 247 (1): 146–53. doi:10.1006/bbrc.1998.8497. PMID 9636670. S2CID 38236434.
1 2 "Entrez Gene: CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)".
1 2 Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
↑ Jeffrey PD, Tong L, Pavletich NP (December 2000). "Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors". Genes Dev. 14 (24): 3115–25. doi:10.1101/gad.851100. PMC 317144. PMID 11124804.

Serrano M, Hannon GJ, Beach D (1993). "A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4". Nature. 366 (6456): 704–7. Bibcode:1993Natur.366..704S. doi:10.1038/366704a0. PMID 8259215. S2CID 4368128.
Ghosh PK, Anderson J, Cohen N, Takeshita K, Atweh GF, Lebowitz P (1993). "Expression of the leukemia-associated gene, p18, in normal and malignant tissues; inactivation of expression in a patient with cleaved B cell lymphoma/leukemia". Oncogene. 8 (10): 2869–72. PMID 8397372.
Simos G, Maison C, Georgatos SD (1996). "Characterization of p18, a component of the lamin B receptor complex and a new integral membrane protein of the avian erythrocyte nuclear envelope". J. Biol. Chem. 271 (21): 12617–25. doi:10.1074/jbc.271.21.12617. PMID 8647873. S2CID 11167920.
Ragione FD, Russo GL, Oliva A, Mercurio C, Mastropietro S, Pietra VD, Zappia V (1996). "Biochemical characterization of p16INK4- and p18-containing complexes in human cell lines" (PDF). J. Biol. Chem. 271 (27): 15942–9. doi:10.1074/jbc.271.27.15942. PMID 8663131. S2CID 22427888.
Lapointe J, Lachance Y, Labrie Y, Labrie C (1996). "A p18 mutant defective in CDK6 binding in human breast cancer cells". Cancer Res. 56 (20): 4586–9. PMID 8840966.
Venkataramani R, Swaminathan K, Marmorstein R (1998). "Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations". Nat. Struct. Biol. 5 (1): 74–81. doi:10.1038/nsb0198-74. PMID 9437433. S2CID 20199775.
Fåhraeus R, Laín S, Ball KL, Lane DP (1998). "Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule". Oncogene. 16 (5): 587–96. doi:10.1038/sj.onc.1201580. PMID 9482104. S2CID 20017992.
Iolascon A, Giordani L, Moretti A, Basso G, Borriello A, Della Ragione F (1998). "Analysis of CDKN2A, CDKN2B, CDKN2C, and cyclin Ds gene status in hepatoblastoma". Hepatology. 27 (4): 989–95. doi:10.1002/hep.510270414. PMID 9537438. S2CID 29827217.
Noh SJ, Li Y, Xiong Y, Guan KL (1999). "Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin-dependent kinase (CDK) 4 and CDK6". Cancer Res. 59 (3): 558–64. PMID 9973200.
Li J, Byeon IJ, Ericson K, Poi MJ, O'Maille P, Selby T, Tsai MD (1999). "Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A". Biochemistry. 38 (10): 2930–40. CiteSeerX 10.1.1.386.342. doi:10.1021/bi982286e. PMID 10074345.
Schreiber M, Muller WJ, Singh G, Graham FL (1999). "Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity". Oncogene. 18 (9): 1663–76. doi:10.1038/sj.onc.1202466. PMID 10208428. S2CID 26097115.
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Korshunov A, Golanov A (2002). "Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome". Arch. Pathol. Lab. Med. 126 (1): 42–8. doi:10.5858/2002-126-0042-IAOPAP. PMID 11800646.
Blais A, Monté D, Pouliot F, Labrie C (2002). "Regulation of the human cyclin-dependent kinase inhibitor p18INK4c by the transcription factors E2F1 and Sp1". J. Biol. Chem. 277 (35): 31679–93. doi:10.1074/jbc.M204554200. PMID 12077144. S2CID 22279111.
Arcellana-Panlilio MY, Egeler RM, Ujack E, Magliocco A, Stuart GC, Robbins SM, Coppes MJ (2002). "Evidence of a role for the INK4 family of cyclin-dependent kinase inhibitors in ovarian granulosa cell tumors". Genes Chromosomes Cancer. 35 (2): 176–81. doi:10.1002/gcc.10108. PMID 12203782. S2CID 27477191.
Komata T, Kanzawa T, Takeuchi H, Germano IM, Schreiber M, Kondo Y, Kondo S (2003). "Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells". Br. J. Cancer. 88 (8): 1277–80. doi:10.1038/sj.bjc.6600862. PMC 2747579. PMID 12698196.
Sánchez-Aguilera A, Delgado J, Camacho FI, Sánchez-Beato M, Sánchez L, Montalbán C, Fresno MF, Martín C, Piris MA, García JF (2004). "Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomas". Blood. 103 (6): 2351–7. doi:10.1182/blood-2003-07-2356. PMID 14645011. S2CID 426364.

External links

CDKN2C human gene location in the UCSC Genome Browser.
CDKN2C human gene details in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000123080 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028551 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8001816-5] 1 2 3 Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG, Xiong Y (January 1995). "Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function". Genes Dev. 8 (24): 2939–52. doi:10.1101/gad.8.24.2939. PMID 8001816.

[pmid9636670-6] Blais A, Labrie Y, Pouliot F, Lachance Y, Labrie C (July 1998). "Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer". Biochem. Biophys. Res. Commun. 247 (1): 146–53. doi:10.1006/bbrc.1998.8497. PMID 9636670. S2CID 38236434.

[entrez-7] 1 2 "Entrez Gene: CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)".

[pmid17353931-8] 1 2 Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid11124804-9] Jeffrey PD, Tong L, Pavletich NP (December 2000). "Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors". Genes Dev. 14 (24): 3115–25. doi:10.1101/gad.851100. PMC 317144. PMID 11124804.

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[8]

[9]

Function

Interactions

References

Further reading

External links