Interleukin-7 receptor subunit alpha (IL7R-α) also known as CD127 (Cluster of Differentiation 127) is a protein that in humans is encoded by the IL7R gene.[5][6]
IL7R-α is a type I cytokine receptor and is a subunit of the functional interleukin-7 receptor and thymic stromal lymphopoietin (TSLP) receptors.
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000168685 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003882 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: IL7R interleukin 7 receptor".
- ↑ Goodwin RG, Friend D, Ziegler SF, Jerzy R, Falk BA, Gimpel S, Cosman D, Dower SK, March CJ, Namen AE (March 1990). "Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily". Cell. 60 (6): 941–51. doi:10.1016/0092-8674(90)90342-C. PMID 2317865. S2CID 45181020.
Further reading
- Akashi K, Kondo M, Weissman IL (1999). "Role of interleukin-7 in T-cell development from hematopoietic stem cells". Immunol. Rev. 165: 13–28. doi:10.1111/j.1600-065X.1998.tb01226.x. PMID 9850848. S2CID 45365828.
- Appasamy PM (1999). "Biological and clinical implications of interleukin-7 and lymphopoiesis". Cytokines Cell. Mol. Ther. 5 (1): 25–39. PMID 10390077.
- Al-Rawi MA, Mansel RE, Jiang WG (2004). "Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours". Histol. Histopathol. 18 (3): 911–23. PMID 12792903.
- Banham AH (2007). "Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells". Trends Immunol. 27 (12): 541–4. doi:10.1016/j.it.2006.10.002. PMID 17045841.
- Nishii K, Kita K, Miwa H, et al. (1992). "c-kit gene expression in CD7-positive acute lymphoblastic leukemia: close correlation with expression of myeloid-associated antigen CD13". Leukemia. 6 (7): 662–8. PMID 1378163.
- Lynch M, Baker E, Park LS, et al. (1992). "The interleukin-7 receptor gene is at 5p13". Hum. Genet. 89 (5): 566–8. doi:10.1007/BF00219186. PMID 1634235. S2CID 8151834.
- Pleiman CM, Gimpel SD, Park LS, et al. (1991). "Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter". Mol. Cell. Biol. 11 (6): 3052–9. doi:10.1128/MCB.11.6.3052. PMC 360143. PMID 2038316.
- Seckinger P, Fougereau M (1994). "Activation of src family kinases in human pre-B cells by IL-7". J. Immunol. 153 (1): 97–109. PMID 7515933.
- van der Plas DC, Smiers F, Pouwels K, et al. (1996). "Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain". Leukemia. 10 (8): 1317–25. PMID 8709637.
- Maraskovsky E, O'Reilly LA, Teepe M, et al. (1997). "Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice". Cell. 89 (7): 1011–9. doi:10.1016/S0092-8674(00)80289-5. PMID 9215624. S2CID 16192745.
- Corcoran AE, Riddell A, Krooshoop D, Venkitaraman AR (1998). "Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor". Nature. 391 (6670): 904–7. Bibcode:1998Natur.391..904C. doi:10.1038/36122. PMID 9495344. S2CID 205024726.
- Puel A, Ziegler SF, Buckley RH, Leonard WJ (1998). "Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency". Nat. Genet. 20 (4): 394–7. doi:10.1038/3877. PMID 9843216. S2CID 25873360.
- Ye SK, Maki K, Kitamura T, et al. (1999). "Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor". Immunity. 11 (2): 213–23. doi:10.1016/S1074-7613(00)80096-5. PMID 10485656.
- Benbernou N, Muegge K, Durum SK (2000). "Interleukin (IL)-7 induces rapid activation of Pyk2, which is bound to Janus kinase 1 and IL-7Ralpha". J. Biol. Chem. 275 (10): 7060–5. doi:10.1074/jbc.275.10.7060. PMID 10702271.
- Roifman CM, Zhang J, Chitayat D, Sharfe N (2000). "A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency". Blood. 96 (8): 2803–7. doi:10.1182/blood.V96.8.2803. PMID 11023514.
- Reche PA, Soumelis V, Gorman DM, et al. (2001). "Human thymic stromal lymphopoietin preferentially stimulates myeloid cells". J. Immunol. 167 (1): 336–43. doi:10.4049/jimmunol.167.1.336. PMID 11418668.
External links
- IL7R+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: P16871 (Human Interleukin-7 receptor subunit alpha) at the PDBe-KB.
- Overview of all the structural information available in the PDB for UniProt: P16872 (Mouse Interleukin-7 receptor subunit alpha) at the PDBe-KB.
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