Blossom

Blossom (voiced by Cathy Cavadini in the What a Cartoon! episodes and the series) is the tactician and self-proclaimed leader of the Powerpuff Girls. She made her first appearance in the pilot episode "A Sticky Situation!", before making her full appearance in the first episode "Monkey See, Doggie Do". Her personality ingredient is "everything nice", her signature color is bright pink, and she has long red-orange waist-length hair worn in a ponytail with a red bow and a pink hair clip with a red heart. She was named for having spoken freely and honestly to the Professor shortly after her creation as shown in The Powerpuff Girls Movie. She is often seen as the most level-headed, intelligent, and composed member of the group and also strong and determined. She is also a master strategist and apt planner.^[10] Her unique power is freezing objects with her breath as seen in the episode "Ice Sore".

In the reboot and Lego Dimensions, voiced by Amanda Leighton, the 2016 version of Blossom is once again depicted as the leader of the team, and she made her first appearance in the episode "Escape from Monster Island" from the 2016 reboot. Her 2016 counterpart is identical to her 1998 counterpart, but there is one difference: her bow is rounder and light red rather than pointy and dark red. She loves organization and hates when things are messy and out of order. She has a perfect attendance record and is an overachiever. She can be stubborn at times, but still comes through. She also has ice breath like her 1998 counterpart. Her trail is bright pink with little squares. Her unique abilities are: Ice breath, genius-level intelligence, microscopic vision, natural leadership skills, and intuitive aptitude. She also can project bright pink energy and manipulate it into various household and office items; an ability her 1998 counterpart in the original show does not possess.

Bubbles

Bubbles (voiced by Tara Strong in the series, and by Kath Soucie in the What a Cartoon! episodes) is the "softest and sweetest" of the three^[10], and the pilot episode "A Sticky Situation!" marks her first appearance, before the first episode "Monkey See, Doggie Do" marks her full appearance. Her signature color is blue, her personality ingredient is "sugar", and she has blonde hair in pigtails. Bubbles is seen as kind and very sweet but she is also capable of extreme rage and can fight monsters just as well as her sisters can. Her best friend is a stuffed octopus doll she calls "Octi", and she also loves animals. She exhibits the ability to both understand multiple languages (mostly Spanish) and communicate with various animals; her unique powers are projecting powerful sonic screams, and creating a shockwave of thunder with a single clap from her hands.^[10]

In the reboot voiced by Kristen Li, the 2016 version of Bubbles has shoulder-length blonde hair in pigtails, just like her original counterpart, except with new blue hair ties and the pigtails being set slightly higher-up than previously. The episode "Escape from Monster Island" marks her first appearance from the 2016 reboot. Bubbles is an animal lover like her 1998 counterpart and usually tries to save the day the nice way. Like her 1998 counterpart, she can be a bit naive but can also get angered very easily. When in bed she has Octi by her side. Her trail is blue with little circles. Unlike her original counterpart, she is shown to have talent with computers and can even create and program her own video games which have become extremely popular among the children in Townsville, including her sisters. Her special abilities include: Animal telepathy, animal empathy, zoolingulism, sound manipulation, sonic waves, sonic blasts, vocal mimicry, hypnotic singing, and multilingualism. She also can project bright blue energy and manipulate it into various animals due to her love for them; an ability her 1998 counterpart in the original show does not possess.

Buttercup

Buttercup (voiced by E. G. Daily) is described as a "tough hotheaded tomboy".^[10] Her personality ingredient is "spice", her signature color is green, and she has short black hair in a flip. She made her first debut in the pilot episode "A Sticky Situation!", then making her full debut in the first episode "Monkey See, Doggie Do". She loves to get dirty, fights hard and plays rough; she does not plan and is all action.^[10] Her unique power is curling her tongue. McCracken originally wanted to name the character "Bud" until a friend suggested the name Buttercup.^[1] According to The Powerpuff Girls Movie, Buttercup really dislikes the name she was given.

In the reboot voiced by Natalie Palamides, the 2016 version of Buttercup's appearance is almost exactly like her original counterpart except she has a cowlick on the back of her head. She made her first debut in the episode "Escape from Monster Island" from the 2016 reboot. She is depicted as a tomboy who loves to get into action and likes to play sports, hanging out with boys and having fun like her 1998 counterpart, She has a fear of spiders like her 1998 counterpart as well. She has a temper that can usually get out of control. She is also the main archenemy of Manboy, who called her "princess", which she hates the most, Blossom and Bubbles attempt to stop her. Her trail is green with little triangles. Unlike her two sisters, she does not possess any special abilities of her own. However, she, like her sisters, can project bright green energy and manipulate it into various weaponry; an ability her 1998 counterpart and her sisters in the original show does not possess.

Professor Utonium

Professor Utonium (voiced by Tom Kane) is a scientist who works in his home in the suburbs of the City of Townsville, and the Powerpuff Girls' creator and father. He made his first appearance in the pilot episode "A Sticky Situation!", before making his full appearance in the first episode "Monkey See, Doggie Do". A stereotypical scientist, his general attire is a white lab coat and black pants. The Professor once housed a chimpanzee named Jojo (later to become Mojo Jojo) as a lab assistant who proved to be reckless and destructive. While the Professor was stirring his perfect girl concoction, Jojo shoved him, causing him to accidentally break a flask containing the mysterious "Chemical X" which spilled into the formula, thus creating the Powerpuff Girls. The Professor is a genius in many fields of science, has shown knowledge in fields such as physics, chemistry, and biology as well as being a skilled inventor. Aside from his role as a scientist, he acts as a parent to the Powerpuff Girls. Although he apparently did not legally "adopt" the girls, everyone who addresses him calls him "their father" and they as "his daughters". The Professor can be strict, easily manipulated, and overprotective at times, but still retains his caring fatherly image. In the episode "Keen for Keane", the girls set up Professor Utonium and their kindergarten teacher Ms. Keane on a date for Valentine's Day, resulting in the two temporarily becoming an item. Also, his first appearance is in the episode "The Stayover" from the 2016 reboot.

The Mayor of Townsville

The Mayor of Townsville (voiced by Tom Kenny in the series and by Jim Cummings in the What a Cartoon! episodes) is generally referred throughout only as "Mayor", although he is referred to as "Barney" by his wife in the episode "Boogie Frights". He is short and elderly with a fringe of white hair around a bald scalp and a thick white mustache. He wears a monocle over his left eye and a small top hat that “floats” just above his head. The Mayor is rather dimwitted but cares deeply about his city. He has a love for pickles and is very childish at times. He sometimes calls the girls for very silly reasons, as seen in the episode "Bubblevicious" when he calls because of a traffic jam. The What a Cartoon! episode "Meat Fuzzy Lumpkins" featured a different Mayor who was younger, taller and more competent than the Mayor of the series.

Ms. Bellum

Ms. Sara Bellum (voiced by Jennifer Martin in the series) is the Mayor's secretary, who often handles issues that the Mayor cannot handle, in a way, is finding her attractive, the camera focusing on her curves, and her face always being obscured. Her name is a pun on the word cerebellum presumably due to her intelligent and wise nature. She also proved to be a capable fighter, battling the villainess Sedusa by herself when the girls were disabled.

Ms. Bellum appears in one episode of the 2016 series ("Bye Bye, Bellum") in a cameo appearance where she has taken a 1,000-day-long vacation and had several mentions; her removal of the reboot was made possibly due to complaints from parents about the character believing to be inappropriate for young children, however viewers were not happy about this decision as they have ignored her perceived strengths and skills.

Ms. Keane

Ms. Keane (voiced by Jennifer Hale and by Kath Soucie in the What-a-Cartoon! episodes) is the kindergarten teacher of Pokey Oaks Kindergarten. She wears an orange shirt, a red vest, brown pants, and has short black hair and light blue eyes. She is patient, wise, understanding, and protective of her students, making her a well-liked, motherly figure. She is also an animal lover, owning a ginger cat named Valentino, and the class pet hamster, Twiggy. Ms. Keane forbids any fighting in school, even if there is a crisis taking place within it; she convinces the girls that there are other ways to solve problems other than fighting as demonstrated in the episodes "Schoolhouse Rocked" and "Imaginary Fiend". She is named after Margaret Keane who was the main influence behind the design of the Powerpuff Girls.

Narrator

Narrator (voiced by Tom Kenny in the series and Craig McCracken in Whoopass Stew and by Ernie Anderson in the What a Cartoon! episodes) is the enthusiastic but unseen narrator of the show. As the comic relief in the show, he often comments on the proceedings of the episode, says things which happen to be hints about the plots of certain episodes, and frequently breaks the fourth wall. He is also shown to be the only connection between the audience and the girls, as he can "talk" to both and even be involved, such as Mojo Jojo transforming him into a dog. In the episode "Simian Says", he is kidnapped by Mojo Jojo, who promptly takes his place as the episode begins.

Talking Dog

Talking Dog (voiced by Tom Kane in the series and by Paul Mercier in the What a Cartoon! episodes) is a small white dog with black ears and nose and a black spot on his back, wearing a red collar with a yellow dog tag. When he stays with the girls he is shown to be blunt, abrasive and insulting, though his demeanor remains straightforward and earnest. He is frequently abused in almost every appearance he makes; as a running gag, no one ever seems to regard his pain and simply ignores him.

Mitch Mitchelson

Mitch Mitchelson (voiced by Tom Kenny) is the bully at Pokey Oaks Kindergarten. Mitch has brownish hair, and wears a black T-shirt with the words "MITCH ROCKS" on the front. Usually talks in a gruff voice; he torments the kids in the class in a few episodes, though he is not a major threat. He is Buttercup's close friend, according to Buttercup in her interview in the DVD features of The Powerpuff Girls Movie. For a brief time he hosted a short segment on Cartoon Network called "Mitch Rocks", where he looked at various things and said whether they "rock" or not.^[11]

Stanley Whitfield

Stanley Whitfield (voiced by Tom Kane) is the anchorman in the television news of Townsville. He communicates on television what happens every time there is important news in the city. Something that stands out about his appearance is that he always has one eye closed.

Mojo Jojo

Mojo Jojo (voiced by Roger L. Jackson) is a mad scientist anthropomorphic chimpanzee with great intelligence, who speaks with a Japanese accent in an overly exaggerated and repetitive manner. His first appearance is in the episode "Monkey See, Doggie Do". As the main antagonist of the series and the Powerpuff Girls' archenemy, Mojo Jojo was Professor Utonium's reckless laboratory chimpanzee, Jojo, before Professor Utonium created the Powerpuff Girls; the same accident that created the Girls gave Jojo his super-intelligence.^[10] He has green skin, pink scleras, sharp teeth, and wears a white glass dome-shaped helmet that covers his oversized, protruding brain. He wears white gloves and boots, a blue suit with a white belt, and a flowing purple cape. Despite his high intelligence, his plans often contain flaws that he overlooks, and he rarely has much success against the Girls, as their superpowers are too much for his inventions. However, he is a master at manipulation and trickery, often fooling the Girls into thinking he has changed despite their constant encounters. Mojo lives in an observatory atop a dormant volcano located in the middle of Townsville's municipal park. Mojo also makes his first appearance in the episode "The Stayover" from the 2016 series, where he has a mother who also appears to be evil.

Fuzzy Lumpkins

Fuzzy Lumpkins^[12] (voiced by Jim Cummings) is a pink Bigfoot bear-like creature with a wide jaw, a green nose, two antennas on his head, big blue overalls, and brown boots, who commonly plays a banjo which he calls "Jo." He was the first villain introduced in the series, appearing in the pilot "Meat Fuzzy Lumpkins," in which he turned the people of Townsville into meat after he lost in a jam contest. He speaks in a southern accent, and lives in the woods next to Townsville. Fuzzy has a limited intellectual capacity, and is not nearly so active and ambitious as most of the villains in the series. He usually limits himself to shooting anyone whom he finds trespassing on his property, though also prone to destructive fits of rage; when angry, Fuzzy turns dark red, grows claws, and his teeth become sharp fangs. Fuzzy (according to Professor Utonium's research) belongs to a race of "Lumpkins"; he has three siblings (Furry, Fluffy, and Hairy), three nephews (Buzzy, Wuzzy, and Scuzzy), and several dozen cousins who closely resemble him.

HIM

HIM (voiced by Tom Kane) is a mysterious, sinister, effeminate, and supernatural demon. His physical appearance is an amalgamation of sorts with lobster-like claws, red/orange skin, pointed ears, a hooked nose, yellow/green eyes and a long curled beard, wearing makeup, a woman's red jacket and skirt, and black stiletto heel boots. His voice ranges from a high-pitched falsetto to a deep, booming basso profondo. HIM's plans are usually psychological in nature, and often consist of manipulating events to either drive the Powerpuff Girls insane or drive wedges between them. HIM possesses various supernatural and demonic abilities such as shapeshifting, mind manipulation, reality warping, various kinds of energy manipulation, and more. Craig McCracken has stated that "HIM" was inspired by the mannerisms of the Chief Blue Meanie in the 1968 film Yellow Submarine.^[13]

Princess Morbucks

Princess Morbucks (voiced by Jennifer Hale) is a spoiled, rich, and bratty little girl, whose partially unseen and mostly mute father allows her to finance various evil plots to destroy the Powerpuff Girls. Her supervillain outfit consists of a yellow, Powerpuff-style dress, black gloves and boots, and a tiara. Her hatred of the girls stems from her rebuffed attempt to become one of them. Her father is "Daddy" Morbucks, a large, rotund man whose face and head are always hidden from the viewer. He dotes on his daughter and usually indulges in her whims, but it is hinted that his patience is limited and Princess fears truly angering him. Thanks to him, Morbucks has access to virtually unlimited financial resources. In the 2016 series, Morbucks is voiced by Haley Mancini and Kelsy Abbott, and seeks to kill and replace the Powerpuff Girls rather than simply join them.

The Gangreen Gang

The Gangreen Gang (sometimes referred as The Ganggreen Gang)^{[lower-alpha 1]} are a gang of five teenage deformed hoodlums and punks who are green-skinned and unhealthy-looking. Not possessing any powers or exceptional abilities, the Gang is normally not too much of a threat to the girls, but have shown themselves to be very dangerous when motivated. They also delight in tormenting those weaker than themselves, especially children and the elderly. The Gangreen Gang lives in an old shack located in Townsville's junkyard.

• Ace (voiced by Jeff Bennett): A mean-spirited and opportunistic rogue with a slick-back hairdo, a colored vest-jacket, a peach-fuzz mustache, a pair of shades, and also has fangs. As the Gang's leader and their smartest member, he is the instigator of most of their antisocial activities, and does possess a certain charismatic charm that allows him to sweet-talk people who ought to know better, such as Ms. Keane in the episode "School House Rocked" and even Buttercup in the episode "Buttercrush". He speaks in a nasally Italian/New Yorker accent. In 2018, Ace temporarily became the replacement bassist of the virtual band Gorillaz while Murdoc Niccals was in prison.^[16]
• Snake (voiced by Tom Kenny in the series): A slippery character with a forked tongue, skinny body, and a hissing voice, Snake is the Gang's second-in-command, but this mostly makes him a yes-man to Ace. He does have a personality of his own, but it is usually silenced due to Ace punching him when he speaks out of line (or asks a foolish question). It is revealed in "School House Rocked" that his real name is Sanford D. Ingleberry.
• Lil' Arturo (voiced by Tom Kenny and by Carlos Alazraqui in his first appearance): A malevolent Mexican little boy, Lil' Arturo seems to take the most amusement from the Gang's activities. In the episode "School House Rocked" he carries around a switchblade-styled comb he calls "Maria", a treasured gift from his incarcerated father. He has a rather prominent underbite. His full name is Arturo de la Guerra, which is Spanish for "Arthur from the War". His small size allows him to sneak through cramped spaces and passages that the rest of the gang cannot reach.
• Grubber (voiced by Jeff Bennett): A disfigured, barefoot hunchback with untidy hair, grubby clothes, and protruding eyes. He also appears to be mostly mute, communicating instead through blowing a raspberry. He does, however, occasionally demonstrate unexpected talents, such as playing the violin, speaking eloquently or performing impersonations. When attending the girls' school for a short time, Grubber showed that he was able to horribly contort his body, making him briefly resemble a well-spoken and handsome-looking young man before snapping back to his normal self.
• Big Billy (voiced by Jeff Bennett): A hulking, dimwitted colossus who acts as the Gang's muscle. Though he does at times display a childlike innocence, he mostly just does the bidding of his more savvy and vindictive friends. In the episode "School House Rocked", it is revealed that his real name is William W. Williams and that he is a cyclops, with his single eye hidden beneath his shaggy red hair. Although he rarely fares any better in combat against the girls than the rest of the gang, he has the muscular power to stop a speeding train from running down citizens from the track and tackle monsters to the ground with his bare hands. He is fiercely loyal to anyone he considers to be a friend, and briefly tried to help the Powerpuff Girls after they saved him from being run over by a train. However, his clumsiness and lack of intelligence made him more destructive as a hero than he was as a villain.

The Amoeba Boys

The Amoeba Boys (voiced by Chuck McCann in the series and the What a Cartoon! episodes and by Lou Romano in Whoopass Stew) are a trio of amoebae who are the villains featured in McCracken's original short, Whoopass Stew in A Sticky Situation. They reappear in the What a Cartoon! short Crime 101. With their mobster affectations, these aspiring criminals would love nothing more than to be regarded as serious villains worthy of fighting, and even getting beaten up and sent to jail by the Powerpuff Girls. Unfortunately, their brains are too primitive to devise a crime above the level of littering or jaywalking. Indeed, they considered stealing an orange to be their greatest crime ever in the episode "Divide and Conquer". They are Townsville's least malicious villains, even having a friendship-of-sorts with the Girls. They are generally harmless, but their actions have on occasion endangered both the Girls and the town by accident.

• Bossman: The leader and general spokesman of the Amoeba Boys. He wears a gray fedora. In the pilot Whoopass Stew in A Sticky Situation, he is depicted with a cigar in his mouth.
• Junior: The smallest one of the Amoeba Boys. He wears a black cap and usually repeats whatever Bossman says. In the episode Crime 101, he is named Tiny.
• Slim: The tallest one of the Amoeba Boys. He wears a brown fedora and is even slower and more incompetent than the other two amoebas. In the episode Crime 101, he is called Skinny Slim.

Sedusa

Sedusa (voiced by Jennifer Hale in the series) is a young, beautiful Gorgon-like mistress of disguise and seductress who uses her feminine wiles to influence men to do her bidding, such as Professor Utonium, the Mayor, and the Gangreen Gang. When her identity is revealed, she typically doffs down to her leotard battle suit and fights with her prehensile hair. Her eyes also change color depending on her mood. When she is acting benevolent her eye color is green, but when she is angry, revealing her true villainous nature, her eyes turn red. Similar to Ms. Bellum, Sedusa is withdrawn from the reboot due to female modifications regarding her appearance to be inappropriate.^[17]

The Rowdyruff Boys

The Rowdyruff Boys are the evil male counterparts to the Powerpuff Girls created by Mojo Jojo using a mixture of "snips, snails, and a puppy dog tail" and a radioactive toilet water in his cell in Townsville Prison in the episode called "The Rowdyruff Boys", where it is the Rowdyruff Boys' first appearances. The Rowdyruff Boys are essentially violent bullies who have the same powers as the Powerpuff Girls, with their own techniques as well. They were ultimately destroyed when the girls kissed them. After being resurrected by HIM in the episode "The Boys Are Back in Town", the Boys' hairstyles become noticeably spikier. The Boys wear long-sleeved shirts with a black stripe in each, black trousers and black, low-top sneakers with white laces and white soles. They also made their only debuts and cameos in the episode "Total Eclipse of the Kart" from the 2016 reboot. Where they are racing against the villains and the Powerpuff Girls, then they immediately got shot by their own "creator" Mojo to arm the missles at the boys.

• Brick (voiced by Rob Paulsen in the series): Blossom's equivalent, he is the short-tempered, self-proclaimed leader of the Rowdyruff Boys. He has an abrasive and rash attitude, which often causes conflict with his brothers. His signature color is red, and he wears a backwards red baseball cap compared to Blossom's bow. He also originally had bangs, which were replaced with long spiky hair when he was revived.
• Boomer (also voiced by Paulsen in the series): Bubbles' equivalent, he is a loud-mouthed dunce, as opposed to Bubbles' naïve sweetness, and has been known to like disgusting things. After his resurrection, Boomer is shown to be the least intelligent of the boys and he is often bullied and bossed around by his brothers. Boomer's hair parts in a curved fashion like Bubbles', but is longer and spiky on each end, in a wings haircut.
• Butch (voiced by Roger L. Jackson in the series): Buttercup's equivalent. After his resurrection, Butch becomes more hyperactive and overly excited. Butch's hair is spiked upwards, abandoning his previous cowlick from his first appearance. He also shares Buttercup's small triangular hair parting.

Allies

Villains