Brian O'Brien may refer to:
- Brian O'Brien (optical physicist) (1898–1992), American optical physicist and the founder of the Air Force Studies Board
- Brian O'Brien (space scientist) (1934–2020), Australian physicist and space scientist
- Brian O'Brien (rugby union) (1939–2023), Irish rugby union player and coach
See also
- Brian O'Brian, an Italian-American series of television shorts
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