Brandywine Creek may refer to:
Canada
- Brandywine Creek (British Columbia), a tributary of the Cheakamus River
United States
- Brandywine Creek (Big Blue River), in Indiana
- Brandywine Creek (St. Joseph River tributary), in Michigan
- Brandywine Creek (Broken Sword Creek tributary), Crawford County, Ohio
- Brandywine Creek (Cuyahoga River tributary), in Summit County, Ohio
- Brandywine Creek (Quittapahilla Creek tributary), in Lebanon County, Pennsylvania
- Brandywine Creek (Christina River tributary), in Chester County, Pennsylvania and New Castle County, Delaware
- East Branch Brandywine Creek, in Chester County, Pennsylvania
- West Branch Brandywine Creek, in Chester County, Pennsylvania
- Brandywine Creek State Park, in New Castle County, Delaware
- Battle of Brandywine Creek, during the American Revolutionary War (1777)
See also
- Brandywine (disambiguation)
- Baranduin or Brandywine River, a river in Middle-earth in the fiction of J. R. R. Tolkien
- Brandywine Falls (disambiguation)
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