Ayre is a surname. Notable people with the surname include:

• Sir Amos Ayre (1885–1952), English shipbuilder and high-ranking Admiralty official
• Bella Ayre (born 1998), Australian rules footballer
• Billy Ayre (1952–2002), English footballer
• Bobby Ayre (1932–2018), English former footballer
• Calvin Ayre (born 1961), Canadian founder of the Bodog online gaming and entertainment brand
• Charles R. Ayre (1819–1889), Newfoundland merchant and politician
• Colin Ayre (born 1956), English former footballer
• Garry Ayre (born 1953), Canadian former soccer player
• Jack Ayre (1894–1977), Canadian entertainer
• James S. Ayre (1881–1953), businessman and political figure in Newfoundland
• John B. Ayre (1850–1915), merchant and political figure in Newfoundland, son of Charles Ayre
• Keegan Ayre (born 1988), Canadian soccer player
• Kristian Ayre (born 1977), Canadian actor
• Lewis H.M. Ayre (1914–1985), Canadian businessman
• Richard James Ayre, English journalist
• Sanjay Ayre (born 1980), Jamaican sprinter
• William Ayre (1782 or 1783–1855), Canadian educator