Amyand is a surname, and may refer to:
- Claudius Amyand (surgeon) (c.1660–1740), French surgeon
- Claudius Amyand (MP) (1718–1774), English politician and government official
- George Amyand (1720–1766), British politician, physician and merchant
- John Amyand (1751–1780), English Whig politician
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