Leaders

AX Agents

AX, short for Arcanum Cella Ex Dono Dei (Latin for Papal State Affairs Special Operations Section), serves as the special division of the Ministry of Holy Affairs.^[7] The agents are all elite priests and nuns, trained in different arts of combat, many of whom have special abilities granted to them by lost technologies. The members of the AX unit serve under Cardinal Caterina Sforza, and are often referred to as deputy enforcers. They are often sent to investigate issues relating to or involving vampires.

The Department of Inquisition

The Inquisitorial Department is composed of a group of elite fighters who see themselves as soldiers of God. They carry out the Vatican's will under the orders of Cardinal Francesco. Their first mandate is the elimination of all vampires. The members of the Inquisition are known to resort to extreme methods to carry out their orders, and have clashed with Cardinal Caterina's Deputy Enforcers.^[29] It is said that many of the Inquisitors are singled out by the church at a young age, and conditioned to despise anything that goes against the authority and beliefs of the Catholic Church. Because of these violent tendencies, they are also known as the "Fangs of the Church" as mentioned by the AX.

Augusta Vradica (Seth Nightroad)

Voiced by: Yuki Matsuoka (Japanese); Hilary Haag (English)

Augusta Vradica is the Empress of the New Human Empire. Styled "Augusta Vradica, the First and Only", Her real name is Seth Nightroad. She is the youngest of the siblings, and the third Crusnik. A member of the Alliance Aerospace Navy, Seth viewed Lilith as a mother figure and holds Abel in great sisterly affection. When Cain was fatally wounded in an accident, she injected him with 100% Crusnik, restoring his life, but changing him for the worse. After he killed Lilith during the war, Seth joined Abel in confronting him and was the one directly responsible for shooting him out of an airlock.^[15] As a child, she seemed to have an aversion to Cain for some reason, taking Abel's side during an unexplained argument of theirs and going so far as to shrink somewhat into Lilith in fear when Cain later appeared.

Among the four Crusnik siblings, she has spent the most time with Methuselah, but unlike Abel, she does feed on them.^[12] Around 800 years ago, Augusta Vradica led the Methuselah to the lands where the Empire would eventually stand, to save them from persecution. She helped restore nature back to the lands, returning them to their former glory before the Armageddon. She then became the Empress of the New Human Empire, ruling over her kingdom as the heart of the Empire itself. As the Empress, Seth is seen as a mother by her people, and treats her subjects as she would her own children.^[12] However, most of her courtiers and servants have never seen her before in all the centuries that they have served her, mainly due to the heavy veils she wears to cover her appearance as well as the use of a voice modifier. Though she does age, she still appears as a little girl, but is well over nine hundred years old.^[12] It is implied that she does not wish to declare war on the Vatican territories due to her Abel's desire for peace; sideways comments by her have indicated that she has very little faith that a lasting peace is possible. As his sister, she knows Abel very well, and has commented that he is quite popular with the girls for some unknown reason.^[3] Her appearance differs between the manga and anime; she looks like a girl of eight or nine years old in the anime, and in the manga, she claims to be 13 while in disguise and looks somewhat older than that. In both versions she has green eyes, short black hair, and is very small in stature.

During a plot to overthrow her, Seth disguised herself as a tea-seller and a medical student in the human district of the capital city, Byzantium. During that time, she met Ion Fortuna and Sister Esther Blanchett, though neither knew who she was. She later alerted Abel and Asthe when Ion and Esther were in danger, and saved Esther from one of Dietrich's puppets.^[30]

When her Crusnik powers are activated at 40%, Seth's eyes turn red, her lips turn greenish-blue, her voice becomes deeper, and a pair of giant tuning forks made of blood materialize in each of her hands. At what was presumably a tell-tale 80% activation, fairy-styled wings grow from her back in addition to her other traits. In this state, she can almost instantly disintegrate her enemies, turning them into a salt-like substance. Her power is being based on a manipulation of ultrasonic sound waves which she calls "The Fire of Sound".^[12] She has been shown to have a fondness for random odd jobs; the first time Süleyman saw her she was selling flowers, Esther and Ion meet her as a tea seller, and in one of the omakes Abel runs into her several times doing different jobs including bagging groceries, selling tissues, and working as a waitress. Also, she likes the color green so much that, as the Empress, it is the "Imperial" color and only objects associated with her may display it prominently. In the manga, she also owns a small white squirrel named Abel which is seen accompanying her almost everywhere.

During the events of the Trinity Blood Canon Summa Theologica light novel, Seth was compelled to reactivate the massive spaceship Ark when a nuclear attack ordered by Pope Francesco destroyed the Empire's second largest city. From the capital Byzantium, She attempts to destroy the Vatican's nuclear launch facility using the Ark's powerful satellite cannon. As soon as this system is activated, however, Cain and Dietrich appear and take control of the Ark. Abel also arrives and becomes involved with the confrontation between Seth and Cain. Cain reveals that he seeks to crash the Ark onto the Earth. Seth thwarted this plan by sacrificing herself, and when her strength was spent, Cain killed her and severed her head. After the incident, the Rosenkreuz Orden twists the information and Abel is framed for the murder of Empress Augusta Vradica. This leads the Empire to start an all-out war with the Terrans.^[31]

Mirka Fortuna

Voiced by: Yuri Amano (Japanese); Jennifer Seman (English)

Head of the Imperial Secret Council, the Duchess of Moldova, the Prime Minister of the Empire, and a keeper of Secret History, Mirka Fortuna is known for her cunning and eccentric nature. She is Empress Augusta Vradica's most trusted advisor and friend, being one of the few people in the Empire who knows the Empress' true appearance. Mirka acted as a decoy for the Empress during an assassination plot in order to draw out those behind the plot. Faking her own death, she allowed her grandson, Ion, to be framed for the murder.^[12] For some unknown reason, despite her small stature (she is the same size as Seth in the manga) and frivolous mannerisms, most people who know her seem to be frightened of her in a comedic sort of way, including Ion himself. In the anime, Mirka looks more like a full-grown woman.

Ion Fortuna

Voiced by: Minagawa Junko (Japanese); Aaron Dismuke (English)

Born in 3045 AD, the Earl of Memphis and the Empress's Swords Keeper, Ion Fortuna is very young by Methuselah standards. The grandson of Mirka Fortuna, he is full of pride for both the Empire and his race, and is quite nimble and strong for his age.^[32] He is ordered by the Empress to act as an Imperial messenger and envoy to negotiate with the Vatican. Upon his arrival at the Vatican embassy of Carthage where Caterina was staying, the building caught fire, causing the Vatican's agents to believe that he was involved. He fled from Father Tres' gunfire, but was injured by a silver bullet. Abel and Esther established contact with Ion and Radu, and aided their escape through the underground passages beneath the city.

After learning Radu has betrayed him for the Rosenkreuz Orden, Ion is terribly saddened, but finds comfort in Esther's friendship.^[32] Initially, Ion holds strong prejudices against Terrans, but after his acquaintance and growing familiarity with Esther, his attitude changes considerably,^[29] from the once selfish and human-loathing character seen when he first shows up at the Vatican. Proved when the Puppet Master tries to control him, Ion attempts to commit suicide in order to stop himself from unwillingly killing Esther in a bloodthirsty rage, but is thwarted and saved from this fate by Father Nightroad. Through his experiences with the treachery of the Order, Ion develops a growing desire for vengeance, and eventually joins Abel in his quest to destroy them.^[15]

Ion gradually develops a crush on Esther, which later blossoms into a deep, one-sided love. In the anime, he is very shy about these feelings and has a hard time telling her how he feels.^[12][20] In contrast, Ion is able to confess to Esther in the manga version right before he goes to talk to his grandmother (though it is revealed along the way that he still had to muster up a great amount of courage to do so, blushing furiously when looking back on it.^[33]). Ion treasures his friendship with Esther, but his trust in her is greatly shaken when Radu reveals Esther's past with the Methuselah. Troubled and feeling betrayed, he accuses Esther of secretly thinking him a monster, which she insists is not true. Ion later regrets his actions, especially when Esther arrived to save him before he is killed by Radu, and is captured along with him. His faith in Esther is completely restored when, in jail, she repeats her statement that he is indeed her friend. After the Dietrich awakens his thirst for blood, Ion immediately begs Esther to kill him whilst barely using his willpower to restrain himself. Esther refuses, and instead gently grants him permission to drink her blood. Shocked, touched, and his heart breaking, Ion reluctantly almost gives in to his hunger; he manages to stop himself right before biting her, and almost takes his life before Abel intervenes to save them. Before Esther leaves the Empire, Ion is troubled when completely realizing the fact that because they are of completely different races, he might never see her again. Astha affirms this by reminding him that time passed differently between Methuselah and Terrans, and whatever he desired to say should be said now. At the last moment, Ion catches up to Esther and declares that they will meet again, earning a smile in return. It is relatively unknown if Esther fully understands or shares Ion's feelings. In the anime, she is rather oblivious to it, though in the manga, when Ion promises to become stronger and repeat his invitation for her to remain with him in the Empire, she smiles and states that she will be waiting for him to do so.

Ion's appearances in the manga and anime have slight differences: In the anime, he simply looks like a young boy, but in the manga, he has more androgynous features.

Astharoshe Asran

Voiced by: Michiko Neya (Japanese); Carrie Savage (English)

Astharoshe "Astha" Asran, Viscountess of Odessa and Duchess of Kiev, is an undercover agent for the New Human Empire. She is a direct, no-nonsense individual who has a very low opinion of Terrans, referring to them as barbaric and stupid, among other things. Her opinion of humans, however, seems to have primarily been formed through Empire propaganda combined with having little exposure to or understanding of humans. Asthe takes being called a "vampire" as an insulting slur, and only refers to herself as a Methuselah.^[3] Astha fights with a weapon called the Spear of Gae Bolg. The most powerful close-combat weapon found among the Lost Technology relics, the spear uses ionized xenon gas to create a high-density, high-temperature plasma blade capable of cutting through anything.^[3]

Astha's view of humans begins to change after she is sent to Venice to arrest Endre Kourza, a vampire mass murderer whose newest round of killings in Vatican territory could spur a war. As part of her mission, she is partnered with Father Abel Nightroad from the AX Agency. When the two find Endre, Astha becomes solely focused on killing him because he murdered her partner. She is so blinded by her rage that she destroys the Rialto Bridge, killing and wounding many humans that had come for a festival. Abel also sustains injuries while protecting her from her own sword, which flew back at her in the explosion. She greatly regrets her actions, and keeps a better handle on her emotions when they go after Endre again and arrest him. Though she initially berated Abel for calling himself her partner, a word of special meaning to Astha, at the end of the mission, he earned her respect enough for her to call him her partner.^[3][34] She also became more accepting and tolerating of humans in general. When Ion was framed for the murder of his grandmother, she allowed Abel and his entourage to stay at her estate, and aids Abel in an investigation into the true circumstances of the murder. During the climax of this investigation, she accuses the Duke of Tigris, Süleyman of treason against the Empire, and is forced to kill him after he makes a purposefully unsuccessful attempt on Seth's life. In the manga, she then accompanies Esther to the nuclear launch facility beneath Byzantium. She evidently sees Abel in his 40% Crusnik form, but apparently it does not make any sort of impression on her. She is hit by a fireball when she confronts Radu, and is knocked unconscious, thus she is unaware of both Seth's Crusnik status and her relationship to Abel. She does not appear in this confrontation in the anime.

Her partnership with Abel would become an important step in the secret peace negotiations between the Vatican and the Empire. She would later be assigned to shelter the Vatican diplomats and the Earl of Memphis after the Rosenkreuz Orden's attempt to frame the Earl of Memphis.^[20] Through this turn of events, Astha would also become a core Empire representative in the quest to stop the Rosenkreuz Orden's continued efforts to start another war between the Methuselah and Terrans.

In the novels, the partner that Endre killed was the Countess Len Yearnoshe,^[3] however in the anime series, her partner is changed to a male and it is implied that they were lovers.^[34] In the manga, she owns a very large female tiger named Binas, and cuts her hair short during the conclusion of the Queen of the Night arc because it was singed by a fireball. Her clothing in the manga is much more revealing than in the anime; the portions of her outfit that are absent in the manga are plain white cloth in the anime.

Süleyman

Voiced by: Takewaka Takuma (Japanese); J. Michael Tatum (English)

The third highest ranking noble in the Empire, Duke of Tigris Süleyman has spent over 300 years of his life serving the Empress.^[12] He is the Deputy of the Imperial Secret Council and seems to have known Astharoshe since she was a child and considers himself to be her uncle. After Mirka Fortuna's feigned death, he serves as the Acting-Head of the Imperial Secret Council. In truth, he is the apparent leader of the extremists in the Empire and is part of the plot to assassinate the Empress and the Duchess of Moldova so he can seize the throne.^[35] Süleyman controls the ring of Solomon, which is capable of firing deadly blasts of energy. Despite his hatred and disagreement with the desire for peace between humans and Methuselah, when he has a chance to take a shot at the Empress, he cannot bring himself to kill her and intentionally misses. He is killed by Asthe.^[12]

Baibars

Voiced by: Naoya Uchida (Japanese); Bob Carter (English)

Baibars, the Duke of Khartoum, is a gigantic, dark-skinned man who serves as the chief of the Yeniceri, the Empire's Palace guard.^[20] A loyal subject of the Empire, he is also the bodyguard of the Empress, and is an aggressive and skilled fighter. He is first seen leading a group of Palace Guards to arrest Ion Fortuna, and later appears to intercept Abel's uninvited excursion into the palace.^[20] When Astharoshe Asran and Abel Nightroad sneak into the palace through the catacombs, Baibars and the Yeniceri appear to defeat the Death Hunters sent by Dietrich, allowing the pair to pass safely into the palace. He is introduced as a gruff, dutiful soldier, but after the plot to assassinate the Empress is foiled, he reverts to a much more friendly and easy going personality, as well as revealing that he and all of the Yeniceri are comically terrified of Mirka Fortuna, the Duchess of Moldova. He is currently training Ion in swordsmanship.

Enderles Kudza

Voiced by: Susumu Chiba (Japanese); Chris Patton (English)

Enderles Kudza, Count of Zagreb, is considered the Empire's worst mass murderer, having impaled over 300 Terrans and relentless slaughtering many others in various ways. Boyish in appearance, Enderles is purely evil and was exiled from the Empire. He formed an association with the Rosenkreuz Orden, with Isaak Fernand von Kämpfer acting as his contact. At the Orden's request, he goes to Venice for the purpose of murdering the Pope, however he goes on another massacre spree, killing dozens, in hopes the Empire would send Asthe after him. Having once killed her partner by using Asthe as a shield, he enjoys tormenting her with that knowledge and repeats the scene by using a child as his shield, then killing the little girl the same way he killed Asthe's partner.^[3]

When fighting, Enderles protects himself with an Aegis shield, a series of orbs that forms an impenetrable shield around its wielder. A powerful defense system, the Aegis only weakness is that while activate, the person using it is also unable to attack and must drop the shield to make an offensive move. Asthe, partnered with AX Agent Abel Nightroad, finds Enderles, but he escapes their grasp and Asthe, letting his constant taunting get to her, causes massive casualties among the humans. The pair realize his real purpose for being in Venice, however, and set up a trap for him. Asthe belittled him in order to infuriate him so he will drop his shield and attack her, giving Abel the chance to wound him with a silver bullet. He is arrested, but while he is being transported back to the Empire for his trial, Kämpfer frees him, then kills him.^[3]

In the anime series, Enderles name is changed slightly to Enderle Kudza. His appearance is greatly modified, giving him an older, more adult appearance rather than the childlike appearance described in the novels. The more gruesome details of his crimes, particular his multiple murders of children, are also not mentioned, nor does the anime reveal his connection to Rosenkreuz and his death is mentioned as a result of his wounding by Abel Nightroad.^[20]

Cain Nightroad

Voiced by: Junichi Suwabe (Japanese); Mike McFarland (English) Hirofumi Nojima (young Cain—ep. 24) Kazuya Ichijo (drama CD)

The oldest of the Test Tube Babies, Cain is often seen as Abel's elder twin. He was once the gentle, beloved leader of the Mars Colonization Project, until an accident killed him. Seth injected him with the Crusnik nanomachines which saved his life, but also drove him insane. In the war following the return of the colonialists to Earth, he and Abel took the side of the vampire returners. When Lilith's influence made Abel question their choice, Cain killed her. Furious, Abel and Seth confronted their brother, pushing Cain out of the spaceship and into the atmosphere. His body burned into a pile of ash. Cain was able to regenerate his body from the ash; however, he sometimes has difficulty holding his makeshift body together.^[13]

Nine hundred years later, he met Isaak Fernand von Kämpfer. Together, they took over the Rosenkreuz Orden, a small, insignificant organization in Berlin that consisted of enemies of the Vatican. Through Cain and Isaak's charisma and power, the Orden grew into the world's leading terrorist organization. Cain's motivations are unclear, but he seems bent on the destroying humanity and the world. His subjects refer to him as "Mein Herr" which is German for "My Lord" or "Sir." He is also referred to as "Mein Herr Contra Mundi", German for "My Lord Against the World". His most popular title, however, appears to be Contra Mundi. His overall attitude in the anime is one of aloof disconcern.

Once his brother Abel learns Cain is alive, Abel's primary goal becomes to kill Cain once and for all. When Cain leads the Rosenkreuz Orden on an attack of Albion, the two brothers have their first clash and Cain kills Abel with relative ease due to his higher Crusnik fusion level and Esther's sudden appearance, that distracted Abel.^[13] Realizing Abel had destroyed the control panels of the rocket, he plans to merge himself with Abel's body to get the access codes from Abel's memory.^[14] However, Abel is revived with Lilith's nanomachines thanks to Caterina and Tres. This puts Abel at the same power level as Cain and their next clash ends in a draw. Accompanied by Ion Fortuna, Abel has pledged to hunt Cain for eternity, if need be, until he is destroyed.^[15]

In the manga, Cain's personality is drastically different. While mostly demonstrating an almost childlike, carefree nature most of the time, he was also shown at one point yelling in an over-the-top manner at a vendor who, in his opinion, made poor fish and chips. He has a seemingly random encounter with Esther while she is having an uncomfortable and undesired meeting with a reporter in London. During this encounter, she mistakes him for Abel at first due to their similarities in appearance and manner, though he is dressed in a white suit and a white top hat. He follows her around for some time while she attempts to make her way back to the Royal Palace, all the while acting in an even more frivolous and goofy manner than Abel. Finally, Esther runs into Isaak, posing as Mr. Butler, who tells her that he happens to be looking for someone. This someone is revealed to be Cain who, after listening to Esther telling Issak that she is lost, insists on driving her back to the Palace. When Esther asks him for his name, he momentarily adopts a more solemn manner, and tells her that his name is Cain. The situation resolves itself without any incident, with Cain delivering Esther to the Palace safe and sound and then going on his way. In the manga, Cain seems to be very concerned with Abel's well-being for some reason; he shows great happiness when told by Isaak that Abel is well after his confrontation with Dietrich in the Byzantium nuclear launch facility, and during said confrontation, Dietrich mentions that "a certain someone" would be furious if he was to kill Abel. Why Cain shows this concern is not known.

When his Crusnik powers are activated, Cain's lips and eyes turn red, his hands grow blue claws, he grows six white wings, and a black lance materializes in his hands. In this state, he can generate destructive red energy. When not in Crusnik form, he appears to have the power to launch a destructive and invisible force from his hands and to possess superhuman strength. Among the four Crusniks, Cain is the only one who has fused 100% with his nanomachines in the novels, however in the anime Abel also achieves 100% fusion, without the insanity, after being infused with Lilith's nanomachines.^[15]

Isaak Fernand von Kämpfer

Voiced by: Keiji Fujiwara (Japanese); Christopher Ayres (English)

An inventor of the Rosenkreuz Orden, Isaak is also called Panzer Magier.^[3] Isaak is the vampire who is responsible for making Cain's current body, which had been permanently damaged by Seth and Abel 900 years ago.^[14] Despite his many talents, Isaak is somewhat of a mystery and has gone by many aliases in the past. He used to study at London University under the name of Isaac Butler, and was involved in the incident which killed William's fiancé and led to both to them being expelled. Since he met Cain, Isaak takes care of Cain's regeneration and leads the Orden with him, though his true motivation for doing so is unknown. He enjoys smoking cigarillos and quoting works of literature. Issak does not usually appear in public, preferring to let others carry out his plans. When he does move to the front lines, he shows excellent battle prowess and is not easily defeated.^[21] In the manga, he encounters Esther several times in a black suit and top hat, calling himself Mr. Butler. His reasons for appearing to Esther are seemingly always benevolent; he once went so far as to save her from nearly certain death at the hands of Monica Argento, a ruthless AX agent with orders to bring Esther in dead or alive. His reasons for seemingly shepherding Esther are unknown. Also, he appears to maintain a role as Cain's literal butler in this adaptation, deferring to him in a servant-like manner and referring to himself as an "ant" when compared to Cain. Isaak's calm, mysterious nature and tendency to help the AX as much as the Orden is true in the novels as well, even saving Abel from Monica in a similar situation in Rage Against the Moons.

Isaak possesses many talents and is well versed in the use of Lost Technologies. His primary weapon is an attack called the Arrow of Belial, a massive sphere of light that shoots a multitude of electromagnetically accelerated bolts of energy at his opponent. He also possesses the ability to project a nearly impenetrable electromagnetic wall, known as the Shield of Asmodai, around his body. This defense can be utilized at will and is capable of blocking almost any assault. In addition, Isaak created artificial demons that he can summon into battle to aid him. He has two kinds of demons: dwarfs called the "Schatten Kobolds" that appear to be little devils concealing their forms in Kämpfer's shadow, and knomes, monstrous worm-like creatures with the ability to tunnel through the ground at amazing speeds. The latter only appear in the novels.^[21] He also employs the use of thin mono-carbon fibers, called the Sword of Beelzebub, which are strong enough to cut through the hardest diamond, thus making for another formidable weapon.^[3]

According to the novels, Dietrich von Lohengrin is Isaak's protege and it is probably under his tutelage that Dietrich gained the knowledge to create the Death Hunters.^[21] In the anime, Isaak is last seen piloting the Orden's air ship while leading an attack on the city of Londinium in Albion. Through the combined efforts of the Church and the Kingdom of Albion, the ship was destroyed, presumably killing him in the explosion.^[15]

Dietrich von Lohengrin

Voiced by: Kenichi Suzumura (Japanese); Justin Cook (English)

Born 3042, Dietrich joined the Orden at the age of 7, and by the age of 10 he had earned a high-ranking position. Before joining the Orden, he was the son of the Duke of Germanicus. As a child, he was avoided for his unusual intelligence, and his evil nature. It was for this reason that his father tried to kill him. He failed, and Dietrich killed him along with the rest of his family. After slaughtering his family, Dietrich took over as ruler, and continued living in his home. He continued terrorizing the villagers, until the day he met Cain and Isaak, and joined the Rosenkreuz Orden. Dietrich is the only known Terran in the Orden, and believes that his involvement has a great purpose for the world.

He is extremely beautiful and is said to have the face of an angel but the heart of the devil. Known and feared for his extreme sadism, Dietrich seems to view the world and people in it as his personal toys for use to relieve his constant boredom. After meeting Esther Blanchett, he seems to develop a mild obsession with her, delighting in taunting her and calling her names whenever he is around her. That does not stop him from sending Ion into a bloodthirst while he's locked up with Esther in the dungeons below the palace. He then gives Esther the option of dying at Ion's hands or killing Ion to save herself.^[35]

Dietrich, also known as the Marionettenspieler (Puppet Master), is the creator of the Order's foot soldiers, which he affectionately refers to as Death Hunters. In the anime these puppets are vampire corpses that are controlled using a lost technology that utilizes thin string-like living fibers transplanted on the skin. Once fused into the nervous system, the fibers send out electrical impulses which allow the "puppeteer" to control his victim's nervous system and senses. In the novels they are undead cyborgs resurrected using lost technology. However, his living fibers' ability to be used on living beings as well is found in both versions; this power forces the person under his control to perform tasks against their will and feel sensations such as pain and sexual stimulation. Despite his skills with Lost Technology, it is said that his most fearsome trait is his ability to play with the hearts of other people.

In the anime series, Dietrich fails to gain control of a rocket during a mission in Albion and Cain kills him for his failure.^[13] However, this does not happen in the novels, as Dietrich survives. In the manga, he is threatened with torture after his failure to activate a nuclear weapon underneath Byzantium; evidently not due to said failure but because he mouthed-off to Isaak.

Radu Barvon

Voiced by: Katsuyuki Konishi (Japanese); Jason Liebrecht (English)

The Baron of Luxor and Ion Fortuna's foster brother, Radu is Ion's most trusted friend and is chosen by the Empress to accompany Ion on a mission to negotiate with the Vatican. The visit is ruined when a terrorist bomb causes the Vatican to believe Ion came to kill Cardinal Caterina, and Father Tres attacks him. Abel and Esther meet with Ion and realize it was Radu who set the bomb and betrayed Ion. As a member of the Orden, Radu was given the orders to kill Ion and Cardinal Caterina, to cause a war between the Empire and the Vatican.^[9] Radu appeared to be killed by Sister Paula,^[29] but he reappears a short while later injured, but alive. Note, Sister Paula's appearance in the Ibelis arc is only in the anime.

With Dietrich's help, he seizes control of the Inquisitorial Department's weapons and turns them on the city of Carthage. After Radu severely injures Ion and Brother Petro, Abel activates his 80% Crusnik nanomachines, and kills him.^[9] Radu's sun-burnt dead body is retrieved and repaired by Dietrich, using artificial blood and skin, turning him into a puppet. Though Radu manages to return to his old self to stop Dietrich from using his body to kill Ion, Dietrich is able to quickly regain control and says Radu is no more.^[12] Radu's body is destroyed for good when Seth, in her Crusnik form, disintegrates him.^[12]

Radu possesses the unique ability to produce and control blue flames from which he gained the nickname Flammenschwert (flame sword). After he is turned into a puppet, Dietrich gives his blood the ability to burst into flames.^[12] Radu's fire production and manipulation abilities are due to his being a rare breed of vampires known as Efreet^[37]

In the manga adaptation, Radu appears to be more reluctant in serving the Order, appearing horrified when he finds out about Dietrich's use of vampire corpses in the creation of the "Death Hunters".

Helga von Vogelweide

Novels only

Helga, codenamed Eishexe ("Ice Witch"), holds dominion over cold and ice using the Winter Maiden staff created by Isaak. She is a highly ranked member of the Rosenkreuz, having the same rank as Dietrich von Lohengrin. Helga is in love with Cain and becomes jealous over Isaak's "monopolizing" him. She conspires with the Neumann brothers to kill Isaak and Dietrich and seize their power, but Isaak learns of the plans and kills her.

Balthasar von Neumann

A Methuselah, whose father was apparently a human, Balthasar lives in a castle together with his brothers. He is known to hate unnecessary violence, possessing an artistic nature, and he is a great tactician. Nicknamed Basilisk, Balthasar has the ability to generate a petrifying venom from his palm which can crystallize the living target. He can also petrify his own bodily fluids and fire them in needle-like projectiles. Balthasar is one of the few people Isaak respects, but when Balthasar conspires with Helga, Isaak kills them both.

Melchior von Neumann

The middle von Neumann brother, Melchior is a silent man with a "bent and twisted" personality. He spends a lot of time around Helga, and she seems to be the only one aware of his powers. Melchior can confuse electronic sensors and he can snap Dietrich's puppet strings. Melchior created an army of Auto-Dolls (earning his code name Pygmalion), with the most special one being Siegelind.

Kaspar von Neumann

Born from a Terran father and a Methuselah mother, Kaspar is a noble from Ostmark, Vienna. He is the youngest of the von Neumann brothers. Though he has a very tough looking exterior, Kaspar thinks and refers himself as a woman: the little sister "her" brothers look after and who at times put in shame their good name. He is single-minded and vicious despite his natural intelligence and seemly good-natured personality. Unlike his more sophisticated brothers, Kaspar is deviant enough to drink blood raw but hates the taste of "old men's blood." Like his brothers, he has a special power. He is a polymorph, and can change his appearance very well. For this reason, he is known as Hundert Gesicht (A Hundred Face) - a grammatical error for Hundert Gesichter (A hundred faces).

Under Balthasar's orders, he disguises himself as Caterina Sforza to stab Professor Wordsworth. Against his brothers' approval, he travels alone to Rome to finish off the injured Wordsworth. He ends up dueling with Wordsworth, who leaves his hospital bed to defend Caterina Sforza. Sister Kaya uses the distraction of the battle to burn Kaspar to death.

Guderian

Also known as Reißzahn (fang), who has only spoken once in all his appearances. He works as Isaak's chauffeur and bodyguard. He is apparently a werewolf (possibly a sub-race of the Methuselah). He is extremely ferocious as a werewolf and attacks William and Vanessa. His werewolf form is very large; his back while on four legs is at the same height as Isaak's head and his own head is the same size as Monica Argento's torso. He also possesses incredible reflexes. During his short fight with Monica in the manga, he was able to catch her knife in his mouth and break it, after which he nearly tore her arm off before she retreated. He is able to speak English while in his wolf form, telling Monica to "die" before nearly killing her.

Susanne von Skorzeny

Also known as Red Baronness, nothing much is known about this androgynous woman yet, except that she is a pilot ace, and her only love seems to be her ship. It is hinted that she might be the one responsible for putting Kate in a coma.

Mary Spencer

Voiced by: Miho Yamada (Japanese); Clarine Harp (English)

A colonel of the Albion Navy and a master of the sword, Mary took command of Albion after the death of the queen. Colonel Spencer is a serious type who deals with problems accordingly. After the Pope was kidnapped, she realized that she could not control nor appease the Methuselah the way the Queen had.^[1] In the anime, when Cain Nightroad attacked the palace, Colonel Spencer stood on the front lines with the palace guards in a futile attempt to stop him.^[13] Many of the guards were killed, and Mary was injured.,^[13] after which she stayed loyal to her country and devoted to her duty, by attempting to calm the rebellion until Esther is revealed to be the "Star of Hope" and takes her rightful place as Queen.^[14] In the novels, it is revealed that Mary's mother instigated the rebellion that killed the queen so that Mary could become queen (as she was the daughter of the crown prince), placing the blame for the rebellion on Sir Edward White, the knight that had rescued Esther. Because of this, Mary and Esther end up fighting over the throne instead of working together.

In the manga series, Mary is recast as an antagonist, having slowly poisoned the Queen to death and using the vampire 44th Regiment to massacre the nobles of Albion as revenge for sending Mary and the 44th into a death trap against the Methuselah a year earlier. Mary seeks to install Esther on the throne of Albion, but Esther rejects the plan. Mary then tries to kill Esther but hesitates because they are sisters; Father Tres and Vice Admiral Jane then arrive and defeat the 44th. Mary is wounded and escapes on the Thames. As her getaway boat is about to be apprehended by the Royal Navy, she and her last remaining men are mysterious saved by Isaac von Kampfer.

Virgil Walsh

Voiced by: Yasunori Matsumoto (Japanese); Vic Mignogna (English)

Virgil is a Methuselah who manages the Ghetto and the production of lost technology in Londinium. He tends to stay very calm and relaxed, even in a crisis, and works closely with the government to monitor the factory in the Ghetto. Virgil is also the Count of Manchester, and a privileged member of the House of Manchester.^[1] Though he understands the desire of the enslaved Methuselah to be free, he is against his sister Vanessa's willingness to use violence to accomplish it. He has his hopes in the next generation of rulers, who he feels will see how wrong the situation is and will correct it.^[14]

When the Queen of Albion died, he was assigned the task of searching for the heir to the throne of Albion, known as the "Star of Hope."^[1] After Abel's supposed death and the Rosenkreuz assault on Albion, Virgil goes to the church in Londinium where Esther is mourning for Abel. He reveals to her that she is, in fact, their "Star of Hope", the heir to the throne of Albion and pleads with her to save her people.^[14]

Vanessa Walsh

Voiced by: Akiko Kimura (Japanese); Monica Rial (English)

Unlike her calm and rational brother, Virgil, Vanessa Walsh is much more high strung, angry and short-tempered. Vanessa is also the leader of a Vampire Terrorist Group who attempted to capture Pope Alessandro so that they could use his safety as a bargaining chip.^[1] Despite her anger, she was really hoping to free her people, rather than harm the Pope. Vanessa learned that there were some humans who cared about their hardships when Pope Alessandro XVIII stopped Brother Petros from taking her life. She would later destroy Dietrich's death hunters to save the Pope. She would also help the AX destroy Isaak's ship by explaining the mechanics of defensive shield surrounding the aircraft.

Queen Bridget II

Voiced by: Unknown (Japanese); Pam Dougherty (English)

Brigitte II was the queen of Albion until her death.^[1] At the time of her death, Brigitte II prophesied the coming of Esther Blanchett, the "Star of Hope" to Virgil Walsh. Brigitte's only son, Crown Prince Gilbert, and heir to the throne was previously assassinated by the Order. Though her country is not starkly religious, she is stated as being a Catholic in private. As Queen, she was described as being an amazing person, able to keep the Methuselah from rebelling for years under her leadership.^[1] The Methuselah radicals claim it was done through oppression, and some believe only the younger generation would be able to truly understand them and bring change.

Lilith Sahl

Voiced by: Misa Kobayashi (Japanese); Cynthia Cranz (English)

Lilith was the prototype for Cain, Abel, and Seth and the fourth of the test tube babies created for the Mars Colonization Project by UNASF Scientists. She was in charge of the Health Care area and usually acted as the voice of reason during the conflicts between the Nightroad siblings. During the war, Lilith sided with humanity and the Vatican to save them from the Methuselah, while the three Nightroad siblings joined the Methuselah. Lilith began to convince Abel that his hatred for humans could be wrong. For this, toward the end of the war, Cain tricked her into meeting him for peace and he murdered her. Abel took her body to the Vatican where it lies encased in glass in an underground tomb in Rome. Abel remained in her tomb for 900 years to mourn her death, before rescuing a young Caterina from vampires, leading him to protect the humans as Lilith had. In the anime series, Lilith's Crusnik nanomachines are used to revive Abel from a deathlike state. In the novels, Cain absorbs Crusnik O4's nanomachines.

The anime series never shows Lilith's Crusnik form nor her powers. The novels show her to have beautiful blue wings as Crusnik, and to be a powerful combatant and strategist, protecting humanity from Cain, Seth, Abel, and the Methuselah during the post-Armegeddon Human-Vampire War.

Gyula Kadar

Voiced by: Kenji Nomura (Japanese); Kent Williams (English)

The Marquis of Hungary, Count Gyula was the Methuselah ruler of Istavan along with his beloved wife, Maria. Maria was a computer genius who loved the Church and frequently visited the town to care for and help anyone in need. After his wife was murdered, Gyula was filled with hatred and consumed with the desire for vengeance against the humans, who he believed had killed her. He became a dictator, ruling Istavan with an iron fist through his military police force. He initially tolerated the presence of Saint Matthias Church, because it helped him keep the people under control.^[18] Gyula sent a vampire to attack the clergy at the church, who was injured and arrested by Abel, then sends his troops to attack the clergy member's funeral. Father Abel, Sister Esther and Dietrich rush to his home to stop him from using the "Star of Sorrow," a piece of lost technology that his wife restored, to destroy Rome. After realizing Dietrich was betraying both sides, Abel and Esther are able to stop the satellite and cause it to self-destruct. Gyula, badly wounded from fighting Abel at 40% Crusnik activation, shields Esther from the gunfire of one of his men. He offers to allow Esther to kill him for revenge, but she declines and holds him while he dies.^[17]

The anime telling of the Star of Sorrow arc has some significant differences from the original novels and manga, particularly regarding Gyula's actions. In the anime, he had Bishop Laura murdered for refusing to run the church per his orders, then later had the church burnt to the ground. He captured Father Abel and Sister Esther and forced them to watch as he activated the "Star of Sorrow". After being defeated and the Star self-destructed, he used a dagger to kill himself so that he could die in his own home rather than spend his life in the Vatican dungeons. As he lay dying on the floor, he offered Esther the chance to take her vengeance for Bishop Laura, but she refused and instead comforted him in place of his wife until he died.^[19]