NAA10
Identifiers
AliasesNAA10, ARD1, ARD1A, ARD1P, DXS707, MCOPS1, NATD, TE2, OGDNS, N(alpha)-acetyltransferase 10, NatA catalytic subunit, hARD1, N-alpha-acetyltransferase 10, NatA catalytic subunit
External IDsOMIM: 300013 MGI: 1915255 HomoloGene: 2608 GeneCards: NAA10
Orthologs
SpeciesHumanMouse
Entrez

8260

56292

Ensembl

ENSG00000102030

ENSMUSG00000031388

UniProt

P41227

Q9QY36

RefSeq (mRNA)

NM_003491
NM_001256119
NM_001256120

NM_001177965
NM_019870
NM_001310538

RefSeq (protein)

NP_001243048
NP_001243049
NP_003482

NP_001171436
NP_001297467
NP_063923

Location (UCSC)Chr X: 153.93 – 153.94 MbChr X: 72.96 – 72.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

N-alpha-acetyltransferase 10 (NAA10) also known as NatA catalytic subunit Naa10 and arrest-defective protein 1 homolog A (ARD1A) is an enzyme subunit that in humans is encoded NAA10 gene.[5][6] Together with its auxiliary subunit Naa15, Naa10 constitutes the NatA (Nα-acetyltransferase A) complex that specifically catalyzes the transfer of an acetyl group from acetyl-CoA to the N-terminal primary amino group of certain proteins. In higher eukaryotes, 5 other N-acetyltransferase (NAT) complexes, NatB-NatF, have been described that differ both in substrate specificity and subunit composition.[7]

Gene and transcripts

The human NAA10 is located on chromosome Xq28 and contains 8 exons, 2 encoding three different isoforms derived from alternate splicing.[8] Additionally, a processed NAA10 gene duplication NAA11 (ARD2) has been identified that is expressed in several human cell lines;[9] however, later studies indicate that Naa11 is not expressed in the human cell lines HeLa and HEK293 or in cancerous tissues, and NAA11 transcripts were only detected in testicular and placental tissues.[10] Naa11 has also been found in mouse, where it is mainly expressed in the testis.[11] NAA11 is located on chromosome 4q21.21 in human and 5 E3 in mouse, and only contains two exons. Mice have another Naa10-like paralog, Naa12. Naa12 has NAT activity and genetically compensates for loss of Naa10, while being Naa10/Naa12 null is embryonic lethal in mic.[12]

In mouse, NAA10 is located on chromosome X A7.3 and contains 9 exons. Two alternative splicing products of mouse Naa10, mNaa10235 and mNaa10225, were reported in NIH-3T3 and JB6 cells that may have different activities and function in different subcellular compartments.[13]

Homologues for Naa10 have been identified in almost all kingdoms of life analyzed, including plants,[14][15][16] fungi,[14][17] amoebozoa,[14] archaeabacteria[14][18][19][20] and protozoa.[21][22] In eubacteria, 3 Nα-acetyltransferases, RimI, RimJ and RimL, have been identified[23][24][25] but according to their low sequence identity with the NATs, it is likely that the RIM proteins do not have a common ancestor and evolved independently.[26][27]

Structure

Size-exclusion chromatography and circular dichroism indicated that human Naa10 consists of a compact globular region comprising two thirds of the protein and a flexible unstructured C-terminus.[28] X-ray crystal structure of the 100 kD holo-NatA (Naa10/Naa15) complex from S. pombe showed that Naa10 adopts a typical GNAT fold containing a N-terminal α1–loop–α2 segment that features one large hydrophobic interface and exhibits interactions with its auxiliary subunit Naa15, a central acetyl CoA-binding region, and C-terminal segments that are similar to the corresponding regions in Naa50, another Nα-acetyltransferase.[29] The X-ray crystal structure of archaeal T. volcanium Naa10 has also been reported, revealing multiple distinct modes of acetyl-Co binding involving the loops between β4 and α3, including the P-loop.[20] Non-complexed (Naa15 unbound) Naa10 adopts a different fold: Leu22 and Tyr26 shift out of the active site of Naa10, and Glu24 (important for substrate binding and catalysis of NatA) is repositioned by ~5 Å, resulting in a conformation that allows for the acetylation of a different subset of substrates.[29] An X-ray crystal structure of human Naa10 in complex with Naa15 and HYPK has been reported.[30]

A functional nuclear localization signal in the C-terminus of hNaa10 between residues 78 and 83 (KRSHRR) has been described.[31][32]

Function

Naa10, as part of the NatA complex, is bound to the ribosome and co-translationally acetylates proteins starting with small side chains such as Ser, Ala, Thr, Gly, Val and Cys, after the initiator methionine (iMet) has been cleaved by methionine aminopeptidases (MetAP).[33] Furthermore, post-translational acetylation by non-ribosome-associated Naa10 might occur. About 40-50 % of all proteins are potential NatA substrates.[7][34] Additionally, in a monomeric state, structural rearrangements of the substrate binding pocket Naa10 allow acetylation of N-termini with acidic side chains.[29][35] Furthermore, Nε-acetyltransferase activity[36][37][38][39][40][41][42] and N-terminal propionyltransferase activity [43] have been reported.

Despite the fact that Nα-terminal acetylation of proteins has been known for many years, the functional consequences of this modification are not well understood. However, accumulating evidence have linked Naa10 to various signaling pathways, including Wnt/β-catenin,[38][39][44][45] MAPK,[44] JAK/STAT,[46] and NF-κB,[47][48][49][50] thereby regulating various cellular processes, including cell migration,[51][52] cell cycle control,[53][54][55] DNA damage control,[49][56] caspase-dependent cell death,[56][57] p53 dependent apoptosis,[54] cell proliferation and autophagy [58] as well as hypoxia,[39][40][42][59][60] although there are some major discrepancies regarding hypoxia[61][62][63][64][65] and even isoform specific effects of Naa10 functions have been reported in mouse.[13][66]

Naa10 is essential in D. melanogaster,[67] C. elegans[68] and T. brucei.[21] In S. cerevisiae, Naa10 function is not essential but yNAA10Δ cells display severe defects including de-repression of the silent mating type locus (HML), failure to enter Go phase, temperature sensitivity, and impaired growth.[17][69] Naa10-knockout mice have very recently been reported to be viable, displaying a defect in bone development.[50]

Disease

In 2001 A c.109T>C (p.Ser37Pro) variant in NAA10 was identified in two unrelated families with Ogden Syndrome, a X-linked disorder involving a distinct combination of an aged appearance, craniofacial anomalies, hypotonia, global developmental delays, cryptorchidism, and cardiac arrhythmias.[70] Patient fibroblasts displayed altered morphology, growth and migration characteristics and molecular studies indicate that this S37P mutation disrupts the NatA complex and decreases Naa10 enzymatic activity in vitro and in vivo.[70][71][72]

Furthermore, two other mutations in Naa10 (R116W mutation in a boy and a V107F mutation in a girl) have been described in two unrelated families with sporadic cases of non-syndromic intellectual disabilities, postnatal growth failure, and skeletal anomalies.[73][74] The girl was reported as having delayed closure of the fontanels, delayed bone age, broad great toes, mild pectus carinatum, pulmonary artery stenosis, atrial septal defect, prolonged QT interval. The boy was reported as having small hands/feet, high arched palate, and wide interdental spaces.

Additionally, a splice mutation in the intron 7 splice donor site (c.471+2T→A) of NAA10 was reported in a single family with Lenz microphthalmia syndrome (LMS), a very rare, genetically heterogeneous X-linked recessive disorder characterized by microphthalmia or anophthalmia, developmental delay, intellectual disability, skeletal abnormalities and malformations of teeth, fingers and toes.[75] Patient fibroblasts displayed cell proliferation defects, dysregulation of genes involved in retinoic acid signaling pathway, such as STRA6, and deficiencies in retinol uptake.[75]

Accumulating evidence suggests Naa10 function might regulate co-translational protein folding through the modulation of chaperone function, thereby affecting pathological formation of toxic amyloid aggregates in Alzheimer's disease or prion [PSI+] propagation in yeast.[76][77][78][79]

Further information on NAA10 related syndromes can be found at www.naa10gene.com

Notes

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000102030 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031388 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Tribioli C, Mancini M, Plassart E, Bione S, Rivella S, Sala C, Torri G, Toniolo D (January 1995). "Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae". Hum Mol Genet. 3 (7): 1061–7. doi:10.1093/hmg/3.7.1061. PMID 7981673.
  6. ↑ "Entrez Gene: ARD1A ARD1 homolog A, N-acetyltransferase (S. cerevisiae)".
  7. 1 2 Starheim KK, Gevaert K, Arnesen T (April 2012). "Protein N-terminal acetyltransferases: when the start matters". Trends in Biochemical Sciences. 37 (4): 152–61. doi:10.1016/j.tibs.2012.02.003. PMID 22405572.
  8. ↑ Pruitt KD, Tatusova T, Maglott DR (January 2007). "NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins". Nucleic Acids Research. 35 (Database issue): D61–5. doi:10.1093/nar/gkl842. PMC 1716718. PMID 17130148.
  9. ↑ Arnesen T, Betts MJ, Pendino F, Liberles DA, Anderson D, Caro J, Kong X, Varhaug JE, Lillehaug JR (25 April 2006). "Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase". BMC Biochemistry. 7: 13. doi:10.1186/1471-2091-7-13. PMC 1475586. PMID 16638120.
  10. ↑ Pang AL, Clark J, Chan WY, Rennert OM (November 2011). "Expression of human NAA11 (ARD1B) gene is tissue-specific and is regulated by DNA methylation". Epigenetics. 6 (11): 1391–9. doi:10.4161/epi.6.11.18125. PMC 3242813. PMID 22048246.
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  16. ↑ Bienvenut WV, Sumpton D, Martinez A, Lilla S, Espagne C, Meinnel T, Giglione C (June 2012). "Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-α-acetylation features". Molecular & Cellular Proteomics. 11 (6): M111.015131. doi:10.1074/mcp.m111.015131. PMC 3433923. PMID 22223895.
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  20. 1 2 Ma C, Pathak C, Jang S, Lee SJ, Nam M, Kim SJ, Im H, Lee BJ (October 2014). "Structure of Thermoplasma volcanium Ard1 belongs to N-acetyltransferase family member suggesting multiple ligand binding modes with acetyl coenzyme A and coenzyme A". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1844 (10): 1790–7. doi:10.1016/j.bbapap.2014.07.011. PMID 25062911.
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  47. ↑ Kuo HP, Lee DF, Xia W, Lai CC, Li LY, Hung MC (6 November 2009). "Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation". Biochemical and Biophysical Research Communications. 389 (1): 156–61. doi:10.1016/j.bbrc.2009.08.127. PMC 2753275. PMID 19716809.
  48. ↑ Park J, Kanayama A, Yamamoto K, Miyamoto Y (1 June 2012). "ARD1 binding to RIP1 mediates doxorubicin-induced NF-κB activation". Biochemical and Biophysical Research Communications. 422 (2): 291–7. doi:10.1016/j.bbrc.2012.04.150. PMID 22580278.
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  50. 1 2 Yoon H, Kim HL, Chun YS, Shin DH, Lee KH, Shin CS, Lee DY, Kim HH, Lee ZH, Ryoo HM, Lee MN, Oh GT, Park JW (7 November 2014). "NAA10 controls osteoblast differentiation and bone formation as a feedback regulator of Runx2". Nature Communications. 5: 5176. Bibcode:2014NatCo...5.5176Y. doi:10.1038/ncomms6176. PMID 25376646.
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Further reading

  • Overview of all the structural information available in the PDB for UniProt: P41227 (N-alpha-acetyltransferase 10) at the PDBe-KB.

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