42nd Street most commonly refers to:

• 42nd Street (Manhattan), a major crosstown street in the New York City borough of Manhattan

It may also refer to:

• 42nd Street (film), a 1933 American Warner Bros. musical film with lyrics by Al Dubin, and music by Harry Warren
  • 42nd Street, a 1932 novel by Bradford Ropes which was adapted for the 1933 film and subsequent musical
  • "42nd Street" (song), title song from the film
  • 42nd Street (musical), a 1980 musical with a book by Michael Stewart and Mark Bramble

New York City Subway

• Times Square–42nd Street station, a station complex consisting of:
  • Times Square – 42nd Street (IRT Broadway – Seventh Avenue Line); serving the 1, ​2, and ​3 trains
  • Times Square – 42nd Street (BMT Broadway Line); serving the N, ​Q, ​R, and ​W trains
  • Times Square (IRT 42nd Street Shuttle); the northern terminal of the S (42nd Street Shuttle) train
  • Times Square (IRT Flushing Line), serving the 7 and <7>​ trains
• 42nd Street – Port Authority Bus Terminal (IND Eighth Avenue Line), serving the A, ​C, and ​E trains
• 42nd Street–Bryant Park/Fifth Avenue station, a station complex consisting of:
  • 42nd Street – Bryant Park (IND Sixth Avenue Line), serving the B, ​D, ​F, <F>, and ​M trains
  • Fifth Avenue (IRT Flushing Line), serving the 7 and <7>​ trains
• Grand Central–42nd Street station, a station complex consisting of:
  • Grand Central (IRT 42nd Street Shuttle), the southern terminal of the S (42nd Street Shuttle) train
  • Grand Central – 42nd Street (IRT Lexington Avenue Line); serving the 4, ​5, ​6, and <6> trains
  • Grand Central (IRT Flushing Line), serving the 7 and <7>​ trains
• 42nd Street station (IRT Second Avenue Line), demolished station of the Second Avenue elevated
• 42nd Street station (IRT Third Avenue Line), demolished station of the Third Avenue elevated
• 42nd Street station (IRT Sixth Avenue Line), demolished station of the Sixth Avenue elevated
• 42nd Street station (IRT Ninth Avenue Line), demolished station of the Ninth Avenue elevated
• 42nd Street (IND Second Avenue Line), planned station of the Second Avenue subway

The IRT Flushing Line and IRT 42nd Street Shuttle run under 42nd Street in Manhattan.