| 23S rRNA (adenosine1067-2'-O)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.230 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
23S rRNA (adenosine1067-2'-O)-methyltransferase (EC 2.1.1.230, 23S rRNA A1067 2'-methyltransferase, thiostrepton-resistance methylase, nosiheptide-resistance methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (adenosine1067-2'-O)-methyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + adenosine1067 in 23S rRNA S-adenosyl-L-homocysteine + 2'-O-methyladenosine1067 in 23S rRNA
The methylase that is responsible for autoimmunity in the thiostrepton producer Streptomyces azureus.
References
- ↑ Bechthold A, Floss HG (September 1994). "Overexpression of the thiostrepton-resistance gene from Streptomyces azureus in Escherichia coli and characterization of recognition sites of the 23S rRNA A1067 2'-methyltransferase in the guanosine triphosphatase center of 23S ribosomal RNA". European Journal of Biochemistry. 224 (2): 431–7. doi:10.1111/j.1432-1033.1994.00431.x. PMID 7925357.
- ↑ Thompson J, Schmidt F, Cundliffe E (July 1982). "Site of action of a ribosomal RNA methylase conferring resistance to thiostrepton". The Journal of Biological Chemistry. 257 (14): 7915–7. PMID 6806287.
- ↑ Thompson, J.; Cundliffe, E. (1981). "Purification and properties of an RNA methylase produced by Streptomyces azureus and involved in resistance to thiostrepton". J. Gen. Microbiol. 124: 291–297. doi:10.1099/00221287-124-2-291.
- ↑ Yang H, Wang Z, Shen Y, Wang P, Jia X, Zhao L, Zhou P, Gong R, Li Z, Yang Y, Chen D, Murchie AI, Xu Y (August 2010). "Crystal structure of the nosiheptide-resistance methyltransferase of Streptomyces actuosus". Biochemistry. 49 (30): 6440–50. doi:10.1021/bi1005915. PMID 20550164.
External links
- 23S+rRNA+(adenosine1067-2'-O)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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