116th Street may refer to:

Streets

• 116th Street (Manhattan), a street in the New York City borough of Manhattan

Stations

• 116th Street (IRT Lexington Avenue Line)
• 116th Street (IND Eighth Avenue Line)
• 116th Street (Second Avenue Subway)
• 116th Street (IRT Lenox Avenue Line)
• 116th Street (IRT Third Avenue Line)
• 116th Street (IRT Ninth Avenue Line)
• 116th Street–Columbia University (IRT Broadway–Seventh Avenue Line)
• Rockaway Park–Beach 116th Street (IND Rockaway Line); a station in New York City, in the borough of Queens

Other

• 116th Street Crew, a crew in the Genovese crime family of the New York Mob from the 1960s