110th Street may refer to:

Streets

• 110th Street (Manhattan), a major east–west street in Manhattan, New York City

Stations

• Cathedral Parkway–110th Street (IRT Broadway–Seventh Avenue Line), serving the 1 train
• Cathedral Parkway–110th Street (IND Eighth Avenue Line), serving the A, ​B, and ​C trains
• Central Park North–110th Street (IRT Lenox Avenue Line), serving the 2 and ​3 trains
• 110th Street (IRT Lexington Avenue Line), serving the 4, ​6, and <6> trains
• 110th Street (IRT Ninth Avenue Line), former station

Other

• Across 110th Street, a 1972 American action-crime film
• "Across 110th Street", a song by Bobby Womack from the soundtrack and film of the same name.